Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 60: 532-538, 1986;
8750-7587/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rennard, S. I.
Right arrow Articles by Crystal, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rennard, S. I.
Right arrow Articles by Crystal, R. G.

Journal of Applied Physiology, Vol 60, Issue 2 532-538, Copyright © 1986 by American Physiological Society

ARTICLES

Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

S. I. Rennard, G. Basset, D. Lecossier, K. M. O'Donnell, P. Pinkston, P. G. Martin and R. G. Crystal

Bronchoalveolar lavage is a powerful technique for sampling the epithelial lining fluid (ELF) of the lower respiratory tract but also results in a significant dilution of that fluid. To quantify the apparent volume of ELF obtained by bronchoalveolar lavage, urea was used as an endogenous marker of ELF dilution. Since urea diffuses readily through the body, plasma and in situ ELF urea concentrations are identical; thus ELF volume can be calculated using simple dilution principles. Using this approach, we determined that with a standard lavage procedure, the volume of ELF recovered from a normal human is 1.0 +/- 0.1 ml/100 ml of recovered lavage fluid. Time course experiments in which the saline used for lavage was permitted to remain in the lower respiratory tract for various "dwell times" suggested that diffusion of urea from sources other than recovered ELF can contribute to the total urea recovered resulting in an overestimate of the volume of ELF recovered. Thus, while reasonably accurate, the volume of ELF determined by urea must be considered an overestimate, or "apparent" volume. The ELF albumin concentration based on the apparent ELF volume was 3.7 +/- 0.3 mg/ml, a value that is in good agreement with direct measurements made by other techniques in experimental animals. The density of all inflammatory and immune effector cells on the epithelial surface of the lower respiratory tract, based on the apparent ELF volume, was 21,000 +/- 3,000 cells/microliter, a value that is twofold greater than that in blood.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
J. L. Crandon, M. A. Banevicius, A. F. Fang, P. H. Crownover, R. F. Knauft, J. S. Pope, J. H. Russomanno, E. Shore, D. P. Nicolau, and J. L. Kuti
Bronchopulmonary Disposition of Intravenous Voriconazole and Anidulafungin Given in Combination to Healthy Adults
Antimicrob. Agents Chemother., December 1, 2009; 53(12): 5102 - 5107.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Weiler, G. Falkensammer, A. Hammerer-Lercher, M. Anliker, H. Vogelsinger, M. Joannidis, S. Dunzendorfer, M. Stein, and R. Bellmann
Pulmonary Epithelial Lining Fluid Concentrations after Use of Systemic Amphotericin B Lipid Formulations
Antimicrob. Agents Chemother., November 1, 2009; 53(11): 4934 - 4937.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Subashchandrabose, R. M. LeVeque, T. K. Wagner, R. N. Kirkwood, M. Kiupel, and M. H. Mulks
Branched-Chain Amino Acids Are Required for the Survival and Virulence of Actinobacillus pleuropneumoniae in Swine
Infect. Immun., November 1, 2009; 77(11): 4925 - 4933.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Day, A. Friedman, and L. S. Schlesinger
Modeling the immune rheostat of macrophages in the lung in response to infection
PNAS, July 7, 2009; 106(27): 11246 - 11251.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
E. Kikuchi, J. Kikuchi, Y. Nasuhara, S. Oizumi, A. Ishizaka, and M. Nishimura
Comparison of the Pharmacodynamics of Biapenem in Bronchial Epithelial Lining Fluid in Healthy Volunteers Given Half-Hour and Three-Hour Intravenous Infusions
Antimicrob. Agents Chemother., July 1, 2009; 53(7): 2799 - 2803.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Goutelle, L. Bourguignon, P. H. Maire, M. Van Guilder, J. E. Conte Jr., and R. W. Jelliffe
Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs
Antimicrob. Agents Chemother., July 1, 2009; 53(7): 2974 - 2981.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. R. Patel, K. Swan, X. Li, S. D. Tachado, and H. Koziel
Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV+ persons: potential role of IL-10 and BCL-3
J. Leukoc. Biol., July 1, 2009; 86(1): 53 - 60.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Bergsson, E. P. Reeves, P. McNally, S. H. Chotirmall, C. M. Greene, P. Greally, P. Murphy, S. J. O'Neill, and N. G. McElvaney
LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline
J. Immunol., July 1, 2009; 183(1): 543 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Conway Morris, K. Kefala, T. S. Wilkinson, K. Dhaliwal, L. Farrell, T. Walsh, S. J. Mackenzie, H. Reid, D. J. Davidson, C. Haslett, et al.
C5a Mediates Peripheral Blood Neutrophil Dysfunction in Critically Ill Patients
Am. J. Respir. Crit. Care Med., July 1, 2009; 180(1): 19 - 28.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P Paredi and P J Barnes
The airway vasculature: recent advances and clinical implications
Thorax, May 1, 2009; 64(5): 444 - 450.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K J Fidler, T N Hilliard, A Bush, M Johnson, D M Geddes, M W Turner, E W F W Alton, N J Klein, and J C Davies
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism
Thorax, February 1, 2009; 64(2): 150 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. S. Iyer, A. M. Ramirez, J. D. Ritzenthaler, E. Torres-Gonzalez, S. Roser-Page, A. L. Mora, K. L. Brigham, D. P. Jones, J. Roman, and M. Rojas
Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis
Am J Physiol Lung Cell Mol Physiol, January 1, 2009; 296(1): L37 - L45.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Yamazoe, C. Nishitani, M. Takahashi, T. Katoh, S. Ariki, T. Shimizu, H. Mitsuzawa, K. Sawada, D. R. Voelker, H. Takahashi, et al.
Pulmonary Surfactant Protein D Inhibits Lipopolysaccharide (LPS)-induced Inflammatory Cell Responses by Altering LPS Binding to Its Receptors
J. Biol. Chem., December 19, 2008; 283(51): 35878 - 35888.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Suzuki, T. Sakagami, B. K. Rubin, L. M. Nogee, R. E. Wood, S. L. Zimmerman, T. Smolarek, M. K. Dishop, S. E. Wert, J. A. Whitsett, et al.
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA
J. Exp. Med., November 24, 2008; 205(12): 2703 - 2710.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. D. Sin, S. F. P. Man, A. McWilliams, and S. Lam
Surfactant Protein D and Bronchial Dysplasia in Smokers at High Risk of Lung Cancer
Chest, September 1, 2008; 134(3): 582 - 588.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. Kipnis, K. Hansen, T. Sawa, K. Moriyama, A. Zurawel, A. Ishizaka, and J. Wiener-Kronish
Proteomic Analysis of Undiluted Lung Epithelial Lining Fluid
Chest, August 1, 2008; 134(2): 338 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. A. Wilson, L. W. Kwok, A.-H. Hovav, S. J. Ohle, F. F. Little, A. Fine, and D. N. Kotton
Sustained Expression of {alpha}1-Antitrypsin after Transplantation of Manipulated Hematopoietic Stem Cells
Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 133 - 141.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
T. P. Lodise, M. Kinzig-Schippers, G. L. Drusano, U. Loos, F. Vogel, J. Bulitta, M. Hinder, and F. Sorgel
Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation To Describe the Pharmacodynamic Profile of Cefditoren in Plasma and Epithelial Lining Fluid
Antimicrob. Agents Chemother., June 1, 2008; 52(6): 1945 - 1951.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. W. Johansson, E. A. B. Kelly, W. W. Busse, N. N. Jarjour, and D. F. Mosher
Up-Regulation and Activation of Eosinophil Integrins in Blood and Airway after Segmental Lung Antigen Challenge
J. Immunol., June 1, 2008; 180(11): 7622 - 7635.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
M. Lucchi, B. Damle, A. Fang, P. J. de Caprariis, A. Mussi, S. P. Sanchez, G. Pasqualetti, and M. Del Tacca
Pharmacokinetics of azithromycin in serum, bronchial washings, alveolar macrophages and lung tissue following a single oral dose of extended or immediate release formulations of azithromycin
J. Antimicrob. Chemother., April 1, 2008; 61(4): 884 - 891.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
B. R. Gochuico, N. A. Avila, C. K. Chow, L. J. Novero, H.-P. Wu, P. Ren, S. D. MacDonald, W. D. Travis, M. P. Stylianou, and I. O. Rosas
Progressive Preclinical Interstitial Lung Disease in Rheumatoid Arthritis
Arch Intern Med, January 28, 2008; 168(2): 159 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Kiem and J. J. Schentag
Interpretation of Antibiotic Concentration Ratios Measured in Epithelial Lining Fluid
Antimicrob. Agents Chemother., January 1, 2008; 52(1): 24 - 36.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. H. Gotfried, J.-P. Shaw, B. M. Benton, K. M. Krause, M. R. Goldberg, M. M. Kitt, and S. L. Barriere
Intrapulmonary Distribution of Intravenous Telavancin in Healthy Subjects and Effect of Pulmonary Surfactant on In Vitro Activities of Telavancin and Other Antibiotics
Antimicrob. Agents Chemother., January 1, 2008; 52(1): 92 - 97.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. R. Patel, J. Zhu, S. D. Tachado, J. Zhang, Z. Wan, J. Saukkonen, and H. Koziel
HIV Impairs TNF-{alpha} Mediated Macrophage Apoptotic Response to Mycobacterium tuberculosis
J. Immunol., November 15, 2007; 179(10): 6973 - 6980.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster
Multiple Chemokine Receptors, Including CCR6 and CXCR3, Regulate Antigen-Induced T Cell Homing to the Human Asthmatic Airway
J. Immunol., August 1, 2007; 179(3): 1901 - 1912.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Y. Yeh, E. L. Burnham, M. Moss, and L. A. S. Brown
Chronic Alcoholism Alters Systemic and Pulmonary Glutathione Redox Status
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 270 - 276.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. D. Gregory, L. A. Hogue, T. W. Ferkol, and D. C. Link
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection
Blood, April 15, 2007; 109(8): 3235 - 3243.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. E. Lasbury, S. Merali, P. J. Durant, D. Tschang, C. A. Ray, and C.-H. Lee
Polyamine-mediated Apoptosis of Alveolar Macrophages during Pneumocystis Pneumonia
J. Biol. Chem., April 13, 2007; 282(15): 11009 - 11020.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
C. C. Bauer, P. Jaksch, S. W. Aberle, H. Haber, G. Lang, W. Klepetko, H. Hofmann, and E. Puchhammer-Stockl
Relationship between Cytomegalovirus DNA Load in Epithelial Lining Fluid and Plasma of Lung Transplant Recipients and Analysis of Coinfection with Epstein-Barr Virus and Human Herpesvirus 6 in the Lung Compartment
J. Clin. Microbiol., February 1, 2007; 45(2): 324 - 328.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. Capoluongo, F. Ameglio, P. Lulli, A. Minucci, C. Santonocito, P. Concolino, E. Di Stasio, S. Boccacci, V. Vendettuoli, G. Giuratrabocchetta, et al.
Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants
Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E308 - E313.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. H. Groll, C. A. Lyman, V. Petraitis, R. Petraitiene, D. Armstrong, D. Mickiene, R. M. Alfaro, R. L. Schaufele, T. Sein, J. Bacher, et al.
Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations.
Antimicrob. Agents Chemother., October 1, 2006; 50(10): 3418 - 3423.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Montes-Vizuet, A. Vega-Miranda, E. Valencia-Maqueda, M. C. Negrete-Garcia, J. R. Velasquez, and L. M. Teran
CC chemokine ligand 1 is released into the airways of atopic asthmatics
Eur. Respir. J., July 1, 2006; 28(1): 59 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
B. Capitano, B. A. Potoski, S. Husain, S. Zhang, D. L. Paterson, S. M. Studer, K. R. McCurry, and R. Venkataramanan
Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen.
Antimicrob. Agents Chemother., May 1, 2006; 50(5): 1878 - 1880.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ghosh, A. J. Janocha, M. A. Aronica, S. Swaidani, S. A. A. Comhair, W. Xu, L. Zheng, S. Kaveti, M. Kinter, S. L. Hazen, et al.
Nitrotyrosine Proteome Survey in Asthma Identifies Oxidative Mechanism of Catalase Inactivation
J. Immunol., May 1, 2006; 176(9): 5587 - 5597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. van Heeckeren, M. D. Schluchter, W. Xue, and P. B. Davis
Response to Acute Lung Infection with Mucoid Pseudomonas aeruginosa in Cystic Fibrosis Mice
Am. J. Respir. Crit. Care Med., February 1, 2006; 173(3): 288 - 296.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. M. Kelly, C. M. Greene, G. Meachery, M. O'Mahony, P. M. Gallagher, C. C. Taggart, S. J. O'Neill, and N. G. McElvaney
Endotoxin Up-regulates Interleukin-18: Potential Role for Gram-Negative Colonization in Sarcoidosis
Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1299 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Matalon and S. I. Rennard
Thrombin Increases Lung Water by Decreasing Na,K-ATPase Activity
Am. J. Respir. Cell Mol. Biol., October 1, 2005; 33(4): 317 - 318.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. Effros, B. Peterson, R. Casaburi, J. Su, M. Dunning, J. Torday, J. Biller, and R. Shaker
Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects
J Appl Physiol, October 1, 2005; 99(4): 1286 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
J. Wu, M. Kobayashi, E. A. Sousa, W. Liu, J. Cai, S. J. Goldman, A. J. Dorner, S. J. Projan, M. S. Kavuru, Y. Qiu, et al.
Differential Proteomic Analysis of Bronchoalveolar Lavage Fluid in Asthmatics following Segmental Antigen Challenge
Mol. Cell. Proteomics, September 1, 2005; 4(9): 1251 - 1264.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Panidis, S. L. Markantonis, E. Boutzouka, S. Karatzas, and G. Baltopoulos
Penetration of Gentamicin Into the Alveolar Lining Fluid of Critically Ill Patients With Ventilator-Associated Pneumonia
Chest, August 1, 2005; 128(2): 545 - 552.
[Abstract] [Full Text] [PDF]

Home page
 J Clin PharmacolHome page
O. Burkhardt, J. Majcher-Peszynska, K. Borner, R. Mundkowski, B. Drewelow, H. Derendorf, and T. Welte
Penetration of Ertapenem Into Different Pulmonary Compartments of Patients Undergoing Lung Surgery
J. Clin. Pharmacol., June 1, 2005; 45(6): 659 - 665.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
I. Yike, T. G. Rand, and D. G. Dearborn
Acute Inflammatory Responses to Stachybotrys chartarum in the Lungs of Infant Rats: Time Course and Possible Mechanisms
Toxicol. Sci., April 1, 2005; 84(2): 408 - 417.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G D Perkins, J Roberts, D F McAuley, L Armstrong, A Millar, F Gao, and D R Thickett
Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury
Thorax, February 1, 2005; 60(2): 153 - 158.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. D. Starner, B. Agerberth, G. H. Gudmundsson, and P. B. McCray Jr.
Expression and Activity of {beta}-Defensins and LL-37 in the Developing Human Lung
J. Immunol., February 1, 2005; 174(3): 1608 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. J. Kettle, T. Chan, I. Osberg, R. Senthilmohan, A. L. P. Chapman, T. J. Mocatta, and J. S. Wagener
Myeloperoxidase and Protein Oxidation in the Airways of Young Children with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., December 15, 2004; 170(12): 1317 - 1323.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. T. Diaz, M. D. Wewers, M. King, J. Wade, J. Hart, and T. L. Clanton
Regional Differences in Emphysema Scores and BAL Glutathione Levels in HIV-Infected Individuals
Chest, November 1, 2004; 126(5): 1439 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. van Heeckeren, M. D. Schluchter, M. L. Drumm, and P. B. Davis
Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice
Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L944 - L952.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. E. Conte Jr., J. A. Golden, J. Kipps, M. McIver, and E. Zurlinden
Intrapulmonary Pharmacokinetics and Pharmacodynamics of Itraconazole and 14-Hydroxyitraconazole at Steady State
Antimicrob. Agents Chemother., October 1, 2004; 48(10): 3823 - 3827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. M. Tager, R. L. Kradin, P. LaCamera, S. D. Bercury, G. S. V. Campanella, C. P. Leary, V. Polosukhin, L.-H. Zhao, H. Sakamoto, T. S. Blackwell, et al.
Inhibition of Pulmonary Fibrosis by the Chemokine IP-10/CXCL10
Am. J. Respir. Cell Mol. Biol., October 1, 2004; 31(4): 395 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. E. Conte Jr., J. A. Golden, J. Kipps, and E. Zurlinden
Steady-State Plasma and Intrapulmonary Pharmacokinetics and Pharmacodynamics of Cethromycin
Antimicrob. Agents Chemother., September 1, 2004; 48(9): 3508 - 3515.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
K J Collard, S Godeck, J E Holley, and M W Quinn
Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2004; 89(5): F412 - F416.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Bayat, K. Louchahi, B. Verdiere, D. Anglade, A. Rahoui, P-M. Sorin, M. Tod, O. Petitjean, F. Fraisse, and F.A. Grimbert
Comparison of 99mTc-DTPA and urea for measuring cefepime concentrations in epithelial lining fluid
Eur. Respir. J., July 1, 2004; 24(1): 150 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Hirsch, K. C. Hansen, A. L. Burlingame, and M. A. Matthay
Proteomics: current techniques and potential applications to lung disease
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L1 - L23.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Pilette, J.N. Francis, S.J. Till, and S.R. Durham
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge
Eur. Respir. J., June 1, 2004; 23(6): 876 - 884.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. J. Day, A. M. van Heeckeren, E. Min, and L. W. Velsor
Role for Cystic Fibrosis Transmembrane Conductance Regulator Protein in a Glutathione Response to Bronchopulmonary Pseudomonas Infection
Infect. Immun., April 1, 2004; 72(4): 2045 - 2051.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. F. Dubin, S. K. Robinson, and J. H. Widdicombe
Secretion of lactoferrin and lysozyme by cultures of human airway epithelium
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L750 - L755.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. van Heeckeren, A. Scaria, M. D. Schluchter, T. W. Ferkol, S. Wadsworth, and P. B. Davis
Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L717 - L726.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. M. van Heeckeren, M. Schluchter, L. Xue, J. Alvarez, S. Freedman, J. St. George, and P. B. Davis
Nutritional Effects on Host Response to Lung Infections with Mucoid Pseudomonas aeruginosa in Mice
Infect. Immun., March 1, 2004; 72(3): 1479 - 1486.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. Capitano, H. M. Mattoes, E. Shore, A. O'Brien, S. Braman, C. Sutherland, and D. P. Nicolau
Steady-State Intrapulmonary Concentrations of Moxifloxacin, Levofloxacin, and Azithromycin in Older Adults
Chest, March 1, 2004; 125(3): 965 - 973.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. T. Spencer, G. Paone, P. M. Krein, F. N. Rouhani, J. Rivera-Nieves, and M. L. Brantly
Role of human neutrophil peptides in lung inflammation associated with {alpha}1-antitrypsin deficiency
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L514 - L520.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. J. Wiedermann, A. J. Mayr, N. C. Kaneider, D. Fuchs, N. J. Mutz, and W. Schobersberger
Alveolar Granulocyte Colony-Stimulating Factor and {alpha}-Chemokines in Relation to Serum Levels, Pulmonary Neutrophilia, and Severity of Lung Injury in ARDS
Chest, January 1, 2004; 125(1): 212 - 219.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. Ganz
Antimicrobial polypeptides
J. Leukoc. Biol., January 1, 2004; 75(1): 34 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. N. Francis, M. R. Jacobson, C. M. Lloyd, I. Sabroe, S. R. Durham, and S. J. Till
CXCR1+CD4+ T Cells in Human Allergic Disease
J. Immunol., January 1, 2004; 172(1): 268 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. G. Laffey, D. Honan, N. Hopkins, J.-M. Hyvelin, J. F. Boylan, and P. McLoughlin
Hypercapnic Acidosis Attenuates Endotoxin-induced Acute Lung Injury
Am. J. Respir. Crit. Care Med., January 1, 2004; 169(1): 46 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Yamazaki, S. Ogura, A. Ishizaka, T. Oh-hara, and M. Nishimura
Bronchoscopic Microsampling Method for Measuring Drug Concentration in Epithelial Lining Fluid
Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1304 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. D. Starner, C. K. Barker, H. P. Jia, Y. Kang, and P. B. McCray Jr.
CCL20 Is an Inducible Product of Human Airway Epithelia with Innate Immune Properties
Am. J. Respir. Cell Mol. Biol., November 1, 2003; 29(5): 627 - 633.
[Abstract] [Full Text]

Home page
 J Antimicrob ChemotherHome page
M. H. Gotfried, L. H. Danziger, and K. A. Rodvold
Steady-state plasma and bronchopulmonary characteristics of clarithromycin extended-release tablets in normal healthy adult subjects
J. Antimicrob. Chemother., September 1, 2003; 52(3): 450 - 456.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. L. Wood, P. Chaiyarit, R. B. Day, Y. Wang, C. T. Schnizlein-Bick, R. L. Gregory, and H. L. Twigg III
Measurements of HIV Viral Loads From Different Levels of the Respiratory Tract
Chest, August 1, 2003; 124(2): 536 - 542.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Neurohr, A-G. Lenz, I. Ding, H. Leuchte, T. Kolbe, and J. Behr
Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers
Eur. Respir. J., July 1, 2003; 22(1): 82 - 87.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
F J Wiedermann, W Lederer, A J Mayr, N Sepp, M Herold, and W Schobersberger
Prospective observational study of antiphospholipid antibodies in acute lung injury and acute respiratory distress syndrome: comparison with catastrophic antiphospholipid syndrome
Lupus, June 1, 2003; 12(6): 462 - 467.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
M. Triggiani, F. Granata, B. Balestrieri, A. Petraroli, G. Scalia, L. Del Vecchio, and G. Marone
Secretory Phospholipases A2 Activate Selective Functions in Human Eosinophils
J. Immunol., March 15, 2003; 170(6): 3279 - 3288.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. L. Gibson, J. Emerson, S. McNamara, J. L. Burns, M. Rosenfeld, A. Yunker, N. Hamblett, F. Accurso, M. Dovey, P. Hiatt, et al.
Significant Microbiological Effect of Inhaled Tobramycin in Young Children with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 841 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. O'Bryan, P. Pinkston, V. Kumaraswami, V. Vijayan, G. Yenokida, H. F. Rosenberg, R. Crystal, E. A. Ottesen, and T. B. Nutman
Localized Eosinophil Degranulation Mediates Disease in Tropical Pulmonary Eosinophilia
Infect. Immun., March 1, 2003; 71(3): 1337 - 1342.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
H. M. Ziglam, D. R. Baldwin, I. Daniels, J. M. Andrews, and R. G. Finch
Rifampicin concentrations in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum following a single 600 mg oral dose in patients undergoing fibre-optic bronchoscopy
J. Antimicrob. Chemother., December 1, 2002; 50(6): 1011 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. J. Coakley, C. Taggart, N. G. McElvaney, and S. J. O'Neill
Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis
Blood, October 16, 2002; 100(9): 3383 - 3391.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. C. Jean, Y. Liu, L. A. Brown, R. E. Marc, E. Klings, and M. Joyce-Brady
gamma -Glutamyl transferase deficiency results in lung oxidant stress in normoxia
Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L766 - L776.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Kohyama, T. A. Wyatt, X. Liu, F.-Q. Wen, T. Kobayashi, Q. Fang, H. J. Kim, and S. I. Rennard
PGD2 Modulates Fibroblast-Mediated Native Collagen Gel Contraction
Am. J. Respir. Cell Mol. Biol., September 1, 2002; 27(3): 375 - 381.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. E. Conte Jr., J. A. Golden, M. McQuitty, J. Kipps, S. Duncan, E. McKenna, and E. Zurlinden
Effects of Gender, AIDS, and Acetylator Status on Intrapulmonary Concentrations of Isoniazid
Antimicrob. Agents Chemother., August 1, 2002; 46(8): 2358 - 2364.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. E. Cogo, L. J. I. Zimmermann, F. Rosso, F. Tormena, P. Gamba, G. Verlato, A. Baritussio, and V. P. Carnielli
Surfactant Synthesis and Kinetics in Infants with Congenital Diaphragmatic Hernia
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 154 - 158.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. K. Stoller, F. Rouhani, M. Brantly, S. Shahin, R. A. Dweik, J. M. Stocks, J. Clausen, E. Campbell, and F. Norton
Biochemical Efficacy and Safety of a New Pooled Human Plasma {alpha}1-Antitrypsin, Respitin*
Chest, July 1, 2002; 122(1): 66 - 74.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. E. Conte Jr., J. A. Golden, J. Kipps, and E. Zurlinden
Intrapulmonary Pharmacokinetics of Linezolid
Antimicrob. Agents Chemother., May 1, 2002; 46(5): 1475 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. Oceandy, B. J. McMorran, S. N. Smith, R. Schreiber, K. Kunzelmann, E. W.F.W. Alton, D. A. Hume, and B. J. Wainwright
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities
Hum. Mol. Genet., May 1, 2002; 11(9): 1059 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Miyazaki, S.-i. Nureki, T. Fukami, T. Shigenaga, M. Ando, K. Ito, H. Ando, K. Sugisaki, T. Kumamoto, and T. Tsuda
Elevated Levels of Thymus- and Activation-regulated Chemokine in Bronchoalveolar Lavage Fluid from Patients with Eosinophilic Pneumonia
Am. J. Respir. Crit. Care Med., April 15, 2002; 165(8): 1125 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J.-I. Kadota, Y. Ishimatsu, T. Iwashita, Y. Matsubara, K. Tomono, M. Tateno, R. Ishihara, C. Muller-Serieys, and S. Kohno
Intrapulmonary Pharmacokinetics of Telithromycin, a New Ketolide, in Healthy Japanese Volunteers
Antimicrob. Agents Chemother., March 1, 2002; 46(3): 917 - 921.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
Y. Ouadrhiri, C. Pilette, R. C. Monteiro, J.-P. Vaerman, and Y. Sibille
Effect of IgA on Respiratory Burst and Cytokine Release by Human Alveolar Macrophages . Role of ERK1/2 Mitogen-Activated Protein Kinases and NF-kappa B
Am. J. Respir. Cell Mol. Biol., March 1, 2002; 26(3): 315 - 332.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J.-B. Stern, O. Bernard, C. Paugam, C. Silve, J. Mantz, M. Aubier, and B. Crestani
Parathyroid Hormone-Related Protein in Epithelial Lining Fluid in Humans Negatively Correlates With the Severity of Lung Injury
Chest, March 1, 2002; 121(3): 852 - 857.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Murakami, D. Iwaki, H. Mitsuzawa, H. Sano, H. Takahashi, D. R. Voelker, T. Akino, and Y. Kuroki
Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-alpha Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2
J. Biol. Chem., February 22, 2002; 277(9): 6830 - 6837.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Soltys, T. Bonfield, J. Chmiel, and M. Berger
Functional IL-10 Deficiency in the Lung of Cystic Fibrosis (cftr-/-) and IL-10 Knockout Mice Causes Increased Expression and Function of B7 Costimulatory Molecules on Alveolar Macrophages
J. Immunol., February 15, 2002; 168(4): 1903 - 1910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Jaffre, M. Dehoux, C. Paugam, A. Grenier, S. Chollet-Martin, J.-B. Stern, J. Mantz, M. Aubier, and B. Crestani
Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure
Am J Physiol Lung Cell Mol Physiol, February 1, 2002; 282(2): L310 - L315.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. E. Conte Jr., J. A. Golden, J. Kipps, E. T. Lin, and E. Zurlinden
Effects of AIDS and Gender on Steady-State Plasma and Intrapulmonary Ethambutol Concentrations
Antimicrob. Agents Chemother., October 1, 2001; 45(10): 2891 - 2896.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
P. Berger, D.-W. Perng, H. Thabrew, S. J. Compton, J. A Cairns, A. R. McEuen, R. Marthan, J.-M. Tunon De Lara, and A. F. Walls
Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells
J Appl Physiol, September 1, 2001; 91(3): 1372 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. J. McMorran, J. S. Palmer, D. P. Lunn, D. Oceandy, E. O. Costelloe, G. R. Thomas, D. A. Hume, and B. J. Wainwright
G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease
Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L740 - L747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. Harper, K. Wu, M. M. J. Chang, K. Yoneda, R. Pan, S. P.-M Reddy, and R. Wu
Activation of Nuclear Factor-kappa B Transcriptional Activity in Airway Epithelial Cells by Thioredoxin but Not by N-Acetyl-Cysteine and Glutathione
Am. J. Respir. Cell Mol. Biol., August 1, 2001; 25(2): 178 - 185.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
D. Honeybourne, D. Banerjee, J. Andrews, and R. Wise
Concentrations of gatifloxacin in plasma and pulmonary compartments following a single 400 mg oral dose in patients undergoing fibre-optic bronchoscopy
J. Antimicrob. Chemother., July 1, 2001; 48(1): 63 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Maitre, S. Boussat, D. Jean, M. Gouge, L. Brochard, B. Housset, S. Adnot, and C. Delclaux
Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury
Eur. Respir. J., July 1, 2001; 18(1): 100 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. M. LILLY, H. NAKAMURA, O. I. BELOSTOTSKY, K. J. HALEY, E. A. GARCIA-ZEPEDA, A. D. LUSTER, and E. ISRAEL
Eotaxin Expression after Segmental Allergen Challenge in Subjects with Atopic Asthma
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1669 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
C. Malazdrewich, T. R. Ames, M. S. Abrahamsen, and S. K. Maheswaran
Pulmonary Expression of Tumor Necrosis Factor Alpha, Interleukin-1 Beta, and Interleukin-8 in the Acute Phase of Bovine Pneumonic Pasteurellosis
Vet. Pathol., May 1, 2001; 38(3): 297 - 310.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. H. Mohamed, A. A. M. T. Mobasher, A.-R. I. Yousef, A. Salah, I. Z. El-Naggar, A. H. A. Ghoneim, and R. W. Light
BAL Neopterin : A Novel Marker for Cell-Mediated Immunity in Patients With Pulmonary Tuberculosis and Lung Cancer
Chest, March 1, 2001; 119(3): 776 - 780.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online