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The effect of increased background resistance on the resistive load threshold for eliciting the respiratory-related evoked potential

Department of Physiological Sciences, University of Florida Gainesville, Florida

Submitted 31 October 2006 ; accepted in final form 7 September 2007

The detection threshold (R₅₀) of resistive (R) loads is a function of the total background resistance (R₀). Increased R₀ increases the R₅₀, but the ratio R₅₀/R₀ remains constant. The respiratory-related evoked potential (RREP) is elicited only by R loads greater than the cognitive detection threshold, R₅₀. We hypothesized that the RREP Nf, P1, and N1 peaks will be elicited only when the added load R/R₀ is greater than the normal detection threshold, R₅₀/R₀ = 0.30. We also hypothesized that when the R₀ is increased by adding extrinsic R, the RREP will not be elicited if the R/R₀ is less than the 0.30 ratio. RREPs were recorded with healthy volunteers (n = 20) respiring through a non-rebreathing valve. Three inspiratory R loads that spanned the R₅₀/R₀ = 0.30 detection threshold were presented in two conditions: 1) no added R₀ (R1 < 0.30, R2 > 0.30, R3 > 0.30); and 2) increased R₀ = 13.3 cmH₂O·l^–1·s (R1 < 0.30, R2 < 0.30, R3 > 0.30). For the control R₀, P1, Nf, and N1 peaks of the RREP were elicited by both R2 and R3, and not present with R1. The increased R₀ decreased R2/R₀ > 1.5 to R2/R₀ < 0.15. With increased R₀, the R1 and R2 loads did not elicit the RREP, but the Nf, P1, and N1 peaks were present for R3. These results demonstrate that the RREP is present if the R is above the cognitive detection threshold, and the RREP is absent if the load is below the detection threshold. When the R₀ is increased to make the R/R₀ less than the detection threshold, the R no longer elicits the RREP.

load detection threshold; respiratory sensation; evoked potentials

This article has been cited by other articles:

				P.-Y. S. Chan and P. W. Davenport Respiratory-related evoked potential measures of respiratory sensory gating J Appl Physiol, October 1, 2008; 105(4): 1106 - 1113. [Abstract] [Full Text] [PDF]