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This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 103/5/1536    most recent 00575.2007v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Mortensen, O. H. Articles by Pedersen, B. K. Search for Related Content PubMed PubMed Citation Articles by Mortensen, O. H. Articles by Pedersen, B. K.

PGC-1β is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family

¹Centre of Inflammation and Metabolism at Department of Infectious Diseases and ²Copenhagen Muscle Research Centre, Rigshospitalet, and ³Centre of Inflammation and Metabolism, Institute of Molecular Biology and Physiology, August Krogh Institute, University of Copenhagen, Copenhagen, Denmark

Submitted 28 May 2007 ; accepted in final form 6 August 2007

We hypothesized that the peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) family of transcriptional coactivators (PGC-1, PGC-1β, and PRC) is differentially regulated by training once daily vs. training twice daily every second day and that this difference might be observed in the acute response to endurance exercise. Furthermore, we hypothesized that expression levels of the PGC-1 family differ with muscular fiber-type composition. Thus, before and after 10 wk of knee extensor endurance training, training one leg once daily and the other leg twice daily every second day, keeping the total amount of training for the legs equal, skeletal muscle mRNA expression levels of PGC-1, PGC-1β, and PRC were determined in young healthy men (n = 7) in response to 3 h of acute exercise. No significant difference was found between the two legs, suggesting that regulation of the PGC-1 family is independent of training protocol. Training decreased PGC-1β in both legs, whereas PGC-1 was increased, but not significantly, in the leg training once daily. PRC did not change with training. Both PGC-1 and PRC were increased by acute exercise both before and after endurance training, whereas PGC-1β did not change. The mRNA levels of the PGC-1 family were examined in different types of human skeletal muscle (triceps, soleus, and vastus lateralis; n = 7). Only the expression level of PGC-1β differed and correlated inversely with percentage of type I fibers. In conclusion, there was no difference between training protocols on the acute exercise and training response of the PGC-1 family. However, training caused a decrease in PGC-1β mRNA levels.

peroxisome proliferator-activated receptor- coactivator-1; peroxisome proliferator-activated receptor- coactivator-1β; peroxisome proliferator-activated receptor- coactivator-1-related cofactor; adaptation; glycogen

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