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J Appl Physiol 103: 1078-1081, 2007. First published July 19, 2007; doi:10.1152/japplphysiol.00299.2007
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Familial aggregation of nasal conditioning capacity

Asli Sahin-Yilmaz, Jayant M. Pinto, Marcy de Tineo, Samy Elwany, and Robert M. Naclerio

Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, Illinois

Submitted 16 March 2007 ; accepted in final form 12 July 2007

In our previous studies on nasal conditioning, we observed a large variability among individuals to condition inspired air. Although we previously investigated various physiological parameters (age, sex, nasal mucosal temperature, heart rate, blood pressure, and nasal volume) that might underlie these differences, we have been unable to explain this variability. Many proteins and molecules, which are under genetic control and could affect nasal conditioning, are involved in water transport,. In this study, we hypothesized that familial factors may contribute to the differences in nasal conditioning capacity (NCC). We performed a prospective study of 47 sibling pairs. Cold dry air was delivered to the nose, and the total water gradient (TWG) was calculated to determine the NCC. We found a highly significant intraclass correlation of 0.53 (P < 0.0001) between sibling pairs for the TWG. These results suggest that there is a familial basis for nasal conditioning and a large enough genetic component to search for genes explaining the observed correlation.

nasal conditioning; genetics; siblings; nose; temperature


Address for reprint requests and other correspondence: R. M. Naclerio, Sect. of Otolaryngology-Head and Neck Surgery, The Univ. of Chicago, 5841 S. Maryland Ave., MC 1035, Chicago, IL 60637






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