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J Appl Physiol 103: 587-593, 2007. First published May 24, 2007; doi:10.1152/japplphysiol.00199.2007
8750-7587/07 $8.00
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Flow-induced shear strain in intima of porcine coronary arteries

Wei Zhang,1 Yi Liu,1 and Ghassan S. Kassab1,2,3

Departments of 1Biomedical Engineering, 2Surgery, and 3Cellular and Integrative Physiology, Indiana University Purdue University Indianapolis, Indianapolis, Indianapolis

Submitted 17 February 2007 ; accepted in final form 15 May 2007

The in vivo circumferential strain has a small variation throughout the vascular system (aorta to arterioles). The axial strain has also been shown to be nearly the same as the circumferential strain under physiological loading. Since the endothelium is mechanically much softer than the media-adventitia in healthy arteries, the porcine intima was considered as a mechanically distinct layer from the media-adventitia in a two-layer computational model. Based on the simulation result, we hypothesize that the flow-induced shear strain in intima can be of similar value as the pressure-induced circumferential strain in healthy coronary arteries, even though the shear stress is orders of magnitude smaller than the circumferential stress. The nearly isotropic deformation (circumferential, axial, and shear strains) may have important implications for mechanical homeostasis of endothelial cells, mechanotransduction, growth, and remodeling of blood vessels.

endothelium; stress; deformation; mechanotransduction


Address for reprint requests and other correspondence: G. S. Kassab, Dept. of Biomedical Engineering, IUPUI, 723 W. Michigan St., Indianapolis, IN 46202 (e-mail: gkassab{at}iupui.edu)






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