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Quantitative trait loci associated with maximal exercise endurance in mice

¹Department of Kinesiology, University of North Carolina-Charlotte, Charlotte, North Carolina; ²Malaria Research Institute, Johns Hopkins University, Baltimore, Maryland; ³Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Durham; and ⁴Department of Biology, University of North Carolina-Charlotte, Charlotte, North Carolina

Submitted 22 November 2006 ; accepted in final form 2 April 2007

The role of genetics in the determination of maximal exercise endurance is unclear. Six- to nine-week-old F₂ mice (n = 99; 60 female, 39 male), derived from an intercross of two inbred strains that had previously been phenotyped as having high maximal exercise endurance (Balb/cJ) and low maximal exercise endurance (DBA/2J), were treadmill tested to estimate exercise endurance. Selective genotyping of the F₂ cohort (n = 12 high exercise endurance; n = 12 low exercise endurance) identified a significant quantitative trait locus (QTL) on chromosome X (53.7 cM, DXMit121) in the entire cohort and a suggestive QTL on chromosome 8 (36.1 cM, D8Mit359) in the female mice. Fine mapping with the entire F₂ cohort and additional informative markers confirmed and narrowed the QTLs. The chromosome 8 QTL (EE8^F) is homologous with two suggestive human QTLs and one significant rat QTL previously linked with exercise endurance. No effect of sex (P = 0.33) or body weight (P = 0.79) on exercise endurance was found in the F₂ cohort. These data indicate that genetic factors in distinct chromosomal regions may affect maximal exercise endurance in the inbred mouse. Whereas multiple genes are located in the identified QTL that could functionally affect exercise endurance, this study serves as a foundation for further investigations delineating the identity of genetic factors influencing maximum exercise endurance.

candidate genes; aerobic capacity; genotyping

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