HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 102/6/2301    most recent 00013.2007v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Wilkins, B. W. Articles by Joyner, M. J. Search for Related Content PubMed PubMed Citation Articles by Wilkins, B. W. Articles by Joyner, M. J.

Preserved reflex cutaneous vasodilation in cystic fibrosis does not include an enhanced nitric oxide-dependent mechanism

Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota

Submitted 31 January 2007 ; accepted in final form 2 April 2007

In humans, vasoactive intestinal peptide (VIP) may play a role in reflex cutaneous vasodilation during body heating. We tested the hypothesis that the nitric oxide (NO)-dependent contribution to active vasodilation is enhanced in the skin of subjects with cystic fibrosis (CF), compensating for sparse levels of VIP. In 2 parallel protocols, microdialysis fibers were placed in the skin of 11 subjects with CF and 12 controls. Lactated Ringer was perfused at one microdialysis site and N^G-nitro-L-arginine methyl ester (2.7 mg/ml) was perfused at a second microdialysis site. Skin blood flow was monitored over each site with laser-Doppler flowmetry. In protocol 1, local skin temperature was increased 0.5°C every 5 s to 42°C, and then it maintained at 42°C for 45 min. In protocol 2, subjects wore a tube-lined suit perfused with water at 50°C, sufficient to increase oral temperature (T_or) 0.8°C. Cutaneous vascular conductance (CVC) was calculated (flux/mean arterial pressure) and scaled as percent maximal CVC (sodium nitroprusside; 8.3 mg/ml). Vasodilation to local heating was similar between groups. The change (%CVC_max) in CVC with NO synthase inhibition on the peak (9 ± 3 vs. 12 ± 5%CVC_max; P = 0.6) and the plateau (45 ± 3 vs. 35 ± 5%CVC_max; P = 0.1) phase of the skin blood flow response to local heating was similar in CF subjects and controls, respectively. Reflex cutaneous vasodilation increased CVC in CF subjects (58 ± 4%CVC_max) and controls (53 ± 4%CVC_max; P = 0.37) and NO synthase inhibition attenuated CVC in subjects with CF (37 ± 6%CVC_max) and controls (35 ± 5%CVC_max; P = 0.8) to a similar degree. Thus the preservation of cutaneous active vasodilation in subjects with CF is not associated with an enhanced NO-dependent vasodilation.

vasoactive intestinal peptide; skin blood flow; thermoregulation

This article has been cited by other articles:

				J. M. Stewart, I. Taneja, N. Raghunath, D. Clarke, and M. S. Medow Intradermal angiotensin II administration attenuates the local cutaneous vasodilator heating response Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H327 - H334. [Abstract] [Full Text] [PDF]

				D. L. Kellogg Jr., G. J. Hodges, C. R. Orozco, T. M. Phillips, J. L. Zhao, and J. M. Johnson Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis J Appl Physiol, September 1, 2007; 103(3): 963 - 968. [Abstract] [Full Text] [PDF]