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This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 102/3/1113    most recent 00553.2006v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Shing, C. M. Articles by Coombes, J. S. Search for Related Content PubMed PubMed Citation Articles by Shing, C. M. Articles by Coombes, J. S.

Effects of bovine colostrum supplementation on immune variables in highly trained cyclists

¹School of Human Movement Studies, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia; ²Faculty of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan; ³Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Tokyo, Japan; ⁴Numico Research Australia Pty Limited, Oakden, South Australia, Australia; and ⁵Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore, New South Wales, Australia

Submitted 16 May 2006 ; accepted in final form 1 November 2006

The aim of this study was to investigate the influence of low-dose bovine colostrum protein concentrate (CPC) supplementation on selected immune variables in cyclists. Twenty-nine highly trained male road cyclists completed an initial 40-km time trial (TT₄₀) and were then randomly assigned to either a supplement (n = 14, 10 g bovine CPC/day) or placebo group (n = 15, 10 g whey protein concentrate/day). After 5 wk of supplementation, the cyclists completed a second TT₄₀. They then completed 5 consecutive days of high-intensity training (HIT) that included a TT₄₀, followed by a final TT₄₀ in the following week. Venous blood and saliva samples were collected immediately before and after each TT₄₀, and upper respiratory illness symptoms were recorded over the experimental period. Compared with the placebo group, bovine CPC supplementation significantly increased preexercise serum soluble TNF receptor 1 during the HIT period (bovine CPC = 882 ± 233 pg/ml, placebo = 468 ± 139 pg/ml; P = 0.039). Supplementation also suppressed the postexercise decrease in cytotoxic/suppressor T cells during the HIT period (bovine CPC = –1.0 ± 2.7%, placebo = –9.2 ± 2.8%; P = 0.017) and during the following week (bovine CPC = 1.4 ± 2.9%, placebo = –8.2 ± 2.8%; P = 0.004). Bovine CPC supplementation prevented a postexercise decrease in serum IgG₂ concentration at the end of the HIT period (bovine CPC = 4.8 ± 6.8%, P = 0.88; placebo = –9.7 ± 6.9%, P = 0.013). There was a trend toward reduced incidence of upper respiratory illness symptoms in the bovine CPC group (P = 0.055). In summary, low-dose bovine CPC supplementation modulates immune parameters during normal training and after an acute period of intense exercise, which may have contributed to the trend toward reduced upper respiratory illness in the bovine CPC group.

tumor necrosis factor receptor 1; CD3⁺8⁺; immunoglobulin