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H₁ and H₂ receptors mediate postexercise hyperemia in sedentary and endurance exercise-trained men and women

Department of Human Physiology, University of Oregon, Eugene, Oregon

Submitted 14 April 2006 ; accepted in final form 26 July 2006

In sedentary individuals, H₁ receptors mediate the early portion of postexercise skeletal muscle hyperemia, whereas H₂ receptors mediate the later portion. It is not known whether postexercise hyperemia also presents in endurance-trained individuals. We hypothesized that the postexercise skeletal muscle hyperemia would also exist in endurance-trained individuals and that combined blockade of H₁ and H₂ receptors would abolish the long-lasting postexercise hyperemia in trained and sedentary individuals. We studied 28 sedentary and endurance trained men and women before and through 90 min after a 60-min bout of cycling at 60% peak O₂ uptake on control and combined H₁- and H₂-receptor antagonist days (fexofenadine and ranitidine). We measured arterial pressure (brachial auscultation) and femoral blood flow (Doppler ultrasound). On the control day, femoral vascular conductance (calculated as flow/pressure) was elevated in all groups 60 min after exercise (sedentary men: 86 ± 35%, trained men, 65 ± 18%; sedentary women, 61 ± 19%, trained women: 59 ± 23%, where is change; all P < 0.05 vs. preexercise). In contrast, on the histamine antagonist day, femoral vascular conductance was not elevated in any of the groups after exercise (sedentary men: 21 ± 17%, trained men: 9 ± 5%, sedentary women: 19 ± 4%, trained women: 11 ± 11%; all P > 0.16 vs. preexercise; all P < 0.05 vs. control day). These data suggest postexercise skeletal muscle hyperemia exists in endurance trained men and women. Furthermore, histaminergic mechanisms produce the long-lasting hyperemia in sedentary and endurance-trained individuals.

skeletal muscle; regional blood flow; histamine; athletes; hypotension

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