Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 101: 1481-1488, 2006. First published July 13, 2006; doi:10.1152/japplphysiol.00319.2006
8750-7587/06 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
101/5/1481    most recent
00319.2006v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhu, M.
Right arrow Articles by Yablonskiy, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhu, M.
Right arrow Articles by Yablonskiy, D. A.

TRANSLATIONAL PHYSIOLOGY

How the body controls brain temperature: the temperature shielding effect of cerebral blood flow

Mingming Zhu,1 Joseph J. H. Ackerman,1,2,4 Alexander L. Sukstanskii,2 and Dmitriy A. Yablonskiy2,3

Departments of 1Chemistry, 2Radiology, 3Physics, and 4Internal Medicine, Washington University, St. Louis, Missouri

Submitted 14 March 2006 ; accepted in final form 6 July 2006

ABSTRACT

Normal brain functioning largely depends on maintaining brain temperature. However, the mechanisms protecting brain against a cooler environment are poorly understood. Reported herein is the first detailed measurement of the brain-temperature profile. It is found to be exponential, defined by a characteristic temperature shielding length, with cooler peripheral areas and a warmer brain core approaching body temperature. Direct cerebral blood flow (CBF) measurements with microspheres show that the characteristic temperature shielding length is inversely proportional to the square root of CBF in excellent agreement with a theoretical model. This "temperature shielding effect" quantifies the means by which CBF prevents "extracranial cold" from penetrating deep brain structures. The effect is crucial for research and clinical applications; the relationship between brain, body, and extracranial temperatures can now be quantitatively predicted.

brain temperature regulation; cerebral metabolism; hypothermia; bioheat equation


Address for reprint requests and other correspondence: D. A. Yablonskiy, Mallinckrodt Institute of Radiology, CB 8227, 4525 Scott Ave., St. Louis, MO 63110 (e-mail: YablonskiyD{at}wustl.edu)




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
C. I. Moore and R. Cao
The Hemo-Neural Hypothesis: On The Role of Blood Flow in Information Processing
J Neurophysiol, May 1, 2008; 99(5): 2035 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Hasegawa, M. F. Piacentini, S. Sarre, Y. Michotte, T. Ishiwata, and R. Meeusen
Influence of brain catecholamines on the development of fatigue in exercising rats in the heat
J. Physiol., January 1, 2008; 586(1): 141 - 149.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. A. Neimark, A.-A. Konstas, A. F. Laine, and J. Pile-Spellman
Integration of jugular venous return and circle of Willis in a theoretical human model of selective brain cooling
J Appl Physiol, November 1, 2007; 103(5): 1837 - 1847.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.