Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 101: 1386-1393, 2006. First published June 22, 2006; doi:10.1152/japplphysiol.00342.2006
8750-7587/06 $8.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
101/5/1386    most recent
00342.2006v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gore, C. J.
Right arrow Articles by Levine, B. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gore, C. J.
Right arrow Articles by Levine, B. D.

Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4,000–5,500 m)

Christopher J. Gore,1 Ferran A. Rodríguez,2,3 Martin J. Truijens,2,4 Nathan E. Townsend,5 James Stray-Gundersen,2 and Benjamin D. Levine2

1Australian Institute of Sport, Canberra, Australia; 2Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas; 3Institut Nacional d'Educació Física de Catalunya, Universitat de Barcelona, Barcelona, Spain; 4Faculty of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; and 5New South Wales Institute of Sport, Sydney, Australia

Submitted 21 March 2006 ; accepted in final form 16 June 2006

This study tested the hypothesis that athletes exposed to 4 wk of intermittent hypobaric hypoxia exposure (3 h/day, 5 days/wk at 4,000–5,500 m) or double-blind placebo increase their red blood cell volume (RCV) and hemoglobin mass (Hbmass) secondary to an increase in erythropoietin (EPO). Twenty-three collegiate level athletes were measured before (Pre) and after (Post) the intervention for RCV via Evans blue (EB) dye and in duplicate for Hbmass using CO rebreathing. Hematological indexes including EPO, soluble transferrin receptor, and reticulocyte parameters were measured on 8–10 occasions spanning the intervention. The subjects were randomly divided among hypobaric hypoxia (Hypo, n = 11) and normoxic (Norm, n = 12) groups. Apart from doubling EPO concentration 3 h after hypoxia there was no increase in any of the measures for either Hypo or Norm groups. The mean change in RCV from Pre to Post for the Hypo group was 2.3% (95% confidence limits = –4.8 to 9.5%) and for the Norm group was –0.2% (–5.7 to 5.3%). The corresponding changes in Hbmass were 1.0% (–1.3 to 3.3%) for Hypo and –0.3% (–2.6 to 3.1%) for Norm. There was good agreement between blood volume (BV) from EB and CO: EB BV = 1.03 x CO BV + 142, r2 = 0.85, P < 0.0001. Overall, evidence from four independent techniques (RCV, Hbmass, reticulocyte parameters, and soluble transferrin receptor) suggests that INTERMITTENT HYPOBARIC HYPOXIA EXPOSURE did not accelerate erythropoiesis despite the increase in serum EPO.

high altitude; erythropoiesis; red cell volume; hemoglobin mass


Address for reprint requests and other correspondence: C. J. Gore, Physiology Dept., Australian Institute of Sport, Leverrier Crescent, Bruce, ACT 2617, Australia or Exercise Physiology Laboratory, School of Education, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia (e-mail: chris.gore{at}ausport.gov.au)




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
T. V. Serebrovskaya, E. B. Manukhina, M. L. Smith, H. F. Downey, and R. T. Mallet
Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?
Experimental Biology and Medicine, June 1, 2008; 233(6): 627 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Truijens, F. A. Rodriguez, N. E. Townsend, J. Stray-Gundersen, C. J. Gore, and B. D. Levine
The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners
J Appl Physiol, February 1, 2008; 104(2): 328 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. A. Rodriguez, M. J. Truijens, N. E. Townsend, J. Stray-Gundersen, C. J. Gore, and B. D. Levine
Performance of runners and swimmers after four weeks of intermittent hypobaric hypoxic exposure plus sea level training
J Appl Physiol, November 1, 2007; 103(5): 1523 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Q. Fu, N. E. Townsend, S. M. Shiller, E. R. Martini, K. Okazaki, S. Shibata, M. J. Truijens, F. A. Rodriguez, C. J. Gore, J. Stray-Gundersen, et al.
Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1977 - R1984.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.