HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 101/2/477    most recent 00042.2006v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Rezende, E. L. Articles by Garland, T. Search for Related Content PubMed PubMed Citation Articles by Rezende, E. L. Articles by Garland, T., Jr.

Maximal oxygen consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary wheel running

Department of Biology, University of California, Riverside, California

Submitted 13 January 2006 ; accepted in final form 27 March 2006

We studied relations between maximal O₂ consumption (O_{2 max}) during forced exercise and subordinate traits associated with blood O₂ transport and cellular respiration in four lines of mice selectively bred for high voluntary wheel running (S lines) and their four nonselected control (C) lines. Previously, we reported O_{2 max} of 59 females at three PO₂ (hypoxia = 14% O₂, normoxia = 21%, hyperoxia = 30%). Here, we test the hypothesis that variation in O_{2 max} can be explained, in part, by hemoglobin concentration and PO₂ necessary to obtain 50% O₂ saturation of Hb (an estimate of Hb affinity for O₂) of the blood as well as citrate synthase activity and myoglobin concentration of ventricles and gastrocnemius muscle. Statistical analyses controlled for body mass, compared S and C lines, and also considered effects of the mini-muscle phenotype (present only in S lines and resulting from a Mendelian recessive allele), which reduces hindlimb muscle mass while increasing muscle mass-specific aerobic capacity. Although S lines had higher O_{2 max} than C, subordinate traits showed no statistical differences when the presence of the mini-muscle phenotype was controlled. However, subordinate traits did account for some of the individual variation in O_{2 max}. Ventricle size was a positive predictor of O_{2 max} at all three PO₂. Blood Hb concentration was a positive predictor of O_{2 max} in S lines but a negative predictor in C lines, indicating that the physiological underpinnings of O_{2 max} have been altered by selective breeding. Mice with the mini-muscle phenotype had enlarged ventricles, with higher mass-specific citrate synthase activity and myoglobin concentration, which may account for their higher O_{2 max} in hypoxia.

cardiac output; experimental evolution; hemoglobin; hypoxia tolerance; myoglobin

This article has been cited by other articles:

				T. H. Meek, B. P. Lonquich, R. M. Hannon, and T. Garland Jr Endurance capacity of mice selectively bred for high voluntary wheel running J. Exp. Biol., September 15, 2009; 212(18): 2908 - 2917. [Abstract] [Full Text] [PDF]

				E. L. Rezende, K. A. Hammond, and M. A. Chappell Cold acclimation in Peromyscus: individual variation and sex effects in maximum and daily metabolism, organ mass and body composition J. Exp. Biol., September 1, 2009; 212(17): 2795 - 2802. [Abstract] [Full Text] [PDF]

				E. M. Dlugosz, M. A. Chappell, D. G. McGillivray, D. A. Syme, and T. Garland Jr Locomotor trade-offs in mice selectively bred for high voluntary wheel running J. Exp. Biol., August 15, 2009; 212(16): 2612 - 2618. [Abstract] [Full Text] [PDF]

				L. E. Wong, T. Garland Jr., S. L. Rowan, and R. T. Hepple Anatomic capillarization is elevated in the medial gastrocnemius muscle of mighty mini mice J Appl Physiol, May 1, 2009; 106(5): 1660 - 1667. [Abstract] [Full Text] [PDF]

				D. G. McGillivray, T. Garland Jr, E. M. Dlugosz, M. A. Chappell, and D. A. Syme Changes in efficiency and myosin expression in the small-muscle phenotype of mice selectively bred for high voluntary running activity J. Exp. Biol., April 1, 2009; 212(7): 977 - 985. [Abstract] [Full Text] [PDF]

				F. R. Gomes, E. L. Rezende, J. L. Malisch, S. K. Lee, D. A. Rivas, S. A. Kelly, C. Lytle, B. B. Yaspelkis III, and T. Garland Jr Glycogen storage and muscle glucose transporters (GLUT-4) of mice selectively bred for high voluntary wheel running J. Exp. Biol., January 15, 2009; 212(2): 238 - 248. [Abstract] [Full Text] [PDF]

				J. Hartmann, T. Garland Jr, R. M. Hannon, S. A. Kelly, G. Munoz, and D. Pomp Fine Mapping of "Mini-Muscle," a Recessive Mutation Causing Reduced Hindlimb Muscle Mass in Mice J. Hered., November 1, 2008; 99(6): 679 - 687. [Abstract] [Full Text] [PDF]

				C. Yilmaz, D. M. Dane, and C. C. W. Hsia Assessing recruitment of lung diffusing capacity in exercising guinea pigs with a rebreathing technique J Appl Physiol, July 1, 2008; 105(1): 316 - 321. [Abstract] [Full Text] [PDF]

				R. M. Hannon, S. A. Kelly, K. M. Middleton, E. M. Kolb, D. Pomp, and T. Garland Jr Phenotypic Effects of the "Mini-Muscle" Allele in a Large HR x C57BL/6J Mouse Backcross J. Hered., February 28, 2008; (2008) esn011v1. [Abstract] [Full Text] [PDF]

				G. A. Russell, E. L. Rezende, and K. A. Hammond Development partly determines the aerobic performance of adult deer mice, Peromyscus maniculatus J. Exp. Biol., January 1, 2008; 211(1): 35 - 41. [Abstract] [Full Text] [PDF]

				L. M. Vaanholt, B. De Jong, T. Garland Jr, S. Daan, and G. H. Visser Behavioural and physiological responses to increased foraging effort in male mice J. Exp. Biol., June 1, 2007; 210(11): 2013 - 2024. [Abstract] [Full Text] [PDF]