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Vital capacity, respiratory muscle strength, and pulmonary gas exchange during long-duration exposure to microgravity

Department of Medicine, University of California, San Diego, La Jolla, California

Submitted 8 November 2005 ; accepted in final form 29 March 2006

Extended exposure to microgravity (µG) is known to reduce strength in weight-bearing muscles and was also reported to reduce respiratory muscle strength. Short- duration exposure to µG reduces vital capacity (VC), a surrogate measure for respiratory muscle strength, for the first few days, with little change in O₂ uptake, ventilation, or end-tidal partial pressures. Accordingly we measured VC, maximum inspiratory and expiratory pressures, and indexes of pulmonary gas exchange in 10 normal subjects (9 men, 1 woman, 39–52 yr) who lived on the International Space Station for 130–196 days in a normoxic, normobaric atmosphere. Subjects were studied four times in the standing and supine postures preflight at sea level at 1 G, approximately monthly in µG, and multiple times postflight. VC in µG was essentially unchanged compared with preflight standing [5.28 ± 0.08 liters (mean ± SE), n = 187; 5.24 ± 0.09, n = 117, respectively; P = 0.03] and considerably greater than that measured supine in 1G (4.96 ± 0.10, n = 114, P < 0.001). There was a trend for VC to decrease after the first 2 mo of µG, but there were no changes postflight. Maximum respiratory pressures in µG were generally intermediate to those standing and supine in 1G, and importantly they showed no decrease with time spent in µG. O₂ uptake and CO₂ production were reduced (12%) in extended µG, but inhomogeneity in the lung was not different compared with short-duration exposure to µG. The results show that VC is essentially unchanged and respiratory muscle strength is maintained during extended exposure to µG, and metabolic rate is reduced.

muscle atrophy; spaceflight; humans

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