Journal of Applied Physiology
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J Appl Physiol 100: 1837-1841, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01009.2005
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Relation between muscle fiber conduction velocity and fiber size in neuromuscular disorders

P. J. Blijham,1 H. J. ter Laak,2,3 H. J. Schelhaas,2 B. G. M. van Engelen,2 D. F. Stegeman,1 and M. J. Zwarts1,2

1Department of Clinical Neurophysiology, Institute of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, and Interuniversity Institute for Fundamental and Clinical Human Movement Sciences, Amsterdam; 2Neuromuscular Centre Nijmegen, Institute of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen; and 3Institute of Neurology and Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Submitted 19 August 2005 ; accepted in final form 17 January 2006

To determine the relation between muscle fiber conduction velocity (MFCV) and muscle fiber diameter (MFD) in pathological conditions, we correlated invasively measured MFCV values with MFD data obtained from muscle needle biopsies in 96 patients with various neuromuscular disorders. MFCV was significantly correlated with MFD and independent of the underlying disorder. Pathological diameter changes were fiber-type dependent, with corresponding MFCVs. A linear equation expresses the relation well: MFCV (m/s) = 0.043·MFD (µm) + 0.83. We conclude that fiber diameter determines MFCV largely independent of the underlying neuromuscular disorders studied.

electromyogram; muscle biopsy; muscle fiber potentials; propagation velocity


Address for reprint requests and other correspondence: P. J. Blijham, Dept. of Clinical Neurophysiology, Institute of Neurology 920, Radboud Univ. Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands (e-mail: p.blijham{at}neuro.umcn.nl)






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