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J Appl Physiol (March 30, 2006). doi:10.1152/japplphysiol.01452.2005
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Submitted on November 16, 2005
Accepted on March 21, 2006

Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise

Shigehiko Ogoh1*, Robert M Brothers1, Quinton Barnes1, Wendy L Eubank1, Megan N Hawkins1, Sushmita Purkayastha1, Albert O-Yurvati1, and Peter B Raven1

1 Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas, United States

* To whom correspondence should be addressed. E-mail: sogoh{at}hsc.unt.edu.

The purpose of this investigation was to examine whether the effect of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest was the same during exercise. Eight men (means ± SE: age 26 ± 1 yr; height 180 ± 3 cm; weight 86 ± 6 kg) participated in the present study. 16 Torr of lower body negative pressure (LBNP) was applied to decrease central venous pressure (CVP) at rest and during steady-state leg cycling at 50% VO2peak (104 ± 20 W). Subsequently, infusions of 25% human serum albumin solution were administered to increase CVP at rest and during exercise. During all protocols, heart rate, arterial blood pressure and CVP were recorded continuously. At each stage of LBNP or albumin infusion, the maximal gain (GMAX) of the carotid-vasomotor baroreflex function curve was measured using the neck pressure and neck suction technique. LBNP reduced CVP and increased the GMAX of the carotid-vasomotor baroreflex function curve at rest (+63 ± 25%, P=0.006) and during exercise (+69 ± 19%, P=0.002). In contrast to the LBNP, increases in CVP resulted in the GMAX of the carotid-vasomotor baroreflex function curve being decreased at rest -8 ± 4% and during exercise -18 ± 5%, (P>0.05). These findings indicate that the relationship between CVP and carotid-vasomotor baroreflex sensitivity was non-linear at rest and during exercise and suggests a saturation load of the cardiopulmonary baroreceptors at which carotid-vasomotor baroreflex sensitivity remains unchanged.




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