Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (September 8, 2005). doi:10.1152/japplphysiol.01430.2004
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
100/1/240    most recent
01430.2004v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Petersson, J.
Right arrow Articles by Mure, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Petersson, J.
Right arrow Articles by Mure, M.
Submitted on December 30, 2004
Accepted on September 2, 2005

Paradoxical redistribution of pulmonary blood flow in prone and supine humans exposed to hypergravity

Johan Petersson1*, Malin Rohdin2, Alejandro Sanchez-Crespo3, Sven Nyren4, Hans Jacobsson5, Stig A. Larsson3, Sten G.E. Lindahl1, Dag Linnarsson2, Robb W. Glenny6, and Margareta Mure1

1 Department of Anesthesiology and Intensive Care, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
2 Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
3 Department of Hosptial Physics, Karolinska University Hospital Solna, 171 76Stockholm, Sweden; Medical Radiation Physics, Department of Oncology-Pathology, Stockholm University and Karolinska Institute, 171 77 Stockholm, Sweden
4 Department of Radiology, Karolinska University Hospital Solna, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
5 Department of Hosptial Physics, Karolinska University Hospital Solna, 171 76Stockholm, Sweden; Department of Radiology, Karolinska University Hospital Solna, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden
6 Department of Anesthesiology and Intensive Care, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden; Department of Medicine and Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA

* To whom correspondence should be addressed. E-mail: johan.petersson{at}karolinska.se.

We hypothesized that exposure to hypergravity in the supine and prone postures causes a redistribution of pulmonary blood flow to dependent lung regions. Four normal subjects were exposed to hypergravity using a human centrifuge. Regional lung perfusion was estimated by single-photon-emission computed tomography (SPECT) after administration of 99mTc-labeled albumin macroaggregates during normal and three times normal gravity conditions in the supine and prone postures. All images were obtained during normal gravity. Exposure to hypergravity caused a redistribution of blood flow from dependent to nondependent lung regions in all subjects in both postures. We speculate that this unexpected and paradoxical redistribution is a consequence of airway closure in dependent lung regions causing alveolar hypoxia and hypoxic vasoconstriction. Alternatively, increased vascular resistance in dependent lung regions is caused by distortion of lung parenchyma. The redistribution of blood flow is likely to attenuate rather than contribute to the arterial desaturation caused by hypergravity.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. K. Prisk, K. Yamada, A. C. Henderson, T. J. Arai, D. L. Levin, R. B. Buxton, and S. R. Hopkins
Pulmonary perfusion in the prone and supine postures in the normal human lung
J Appl Physiol, September 1, 2007; 103(3): 883 - 894.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Petersson, A. Sanchez-Crespo, S. A. Larsson, and M. Mure
Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)
J Appl Physiol, January 1, 2007; 102(1): 468 - 476.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.