Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (January 26, 2006). doi:10.1152/japplphysiol.01416.2005
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
100/6/1867    most recent
01416.2005v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fediuc, S.
Right arrow Articles by Riddell, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fediuc, S.
Right arrow Articles by Riddell, M. C.
Submitted on November 8, 2005
Accepted on January 17, 2006

Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats

Sergiu Fediuc1, Jonathan E. Campbell1, and Michael C. Riddell1*

1 School of Kinesiology and Health Science, Faculty of Pure and Applied Sciences, York University, Toronto, Ontario, Canada

* To whom correspondence should be addressed. E-mail: mriddell{at}yorku.ca.

Adaptations of the hypothalamic pituitary adrenal (HPA) axis to voluntary exercise in rodents are not clear, as most investigations use forced exercise protocols, which are associated with psychological stress. In the present study, we examined the effects of voluntary wheel running on the circadian corticosterone (CORT) rhythm as well as HPA axis responsiveness to, and recovery from restraint stress. Male, Sprague-Dawley rats were divided into exercise (E) and sedentary (S) groups, with E rats having 24h access to running wheels for 5 weeks. Circadian plasma CORT levels were measured at the end of each week, except for week 5 where rats were exposed to 20 minutes of restraint stress, followed by 95 minutes of recovery. Measurements of glucocorticoid receptor (GR) content in the hippocampus and anterior pituitary were performed using western blotting at the termination of the restraint protocol. In week 1, circadian CORT levels were 2-fold higher in E compared to S animals, but progressively decreased in the E group throughout the training protocol to reach similar values observed in S by week 4. During restraint stress and recovery, CORT values were similar between E and S, as was GR content in the hippocampus and pituitary gland following sacrifice. Compared with E, S animals had higher plasma ACTH levels during restraint. Taken together, these data indicate that 5 weeks of wheel running are associated with normal circadian CORT activity, and normal negative feedback inhibition of the HPA axis, as well as, increased adrenal sensitivity to ACTH following restraint stress.




This article has been cited by other articles:


Home page
 FASEB J.Home page
S. A. Wolf, B. Steiner, A. Wengner, M. Lipp, T. Kammertoens, and G. Kempermann
Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus
FASEB J, September 1, 2009; 23(9): 3121 - 3128.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Jankord, R. M. McAllister, V. K. Ganjam, and M. H. Laughlin
Chronic inhibition of nitric oxide synthase augments the ACTH response to exercise
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R728 - R734.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. E. Campbell, N. Rakhshani, S. Fediuc, S. Bruni, and M. C. Riddell
Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training
J Appl Physiol, January 1, 2009; 106(1): 66 - 72.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Z. S. Malek, D. Sage, P. Pevet, and S. Raison
Daily Rhythm of Tryptophan Hydroxylase-2 Messenger Ribonucleic Acid within Raphe Neurons Is Induced by Corticoid Daily Surge and Modulated by Enhanced Locomotor Activity
Endocrinology, November 1, 2007; 148(11): 5165 - 5172.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.