| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique - Hopitaux de Paris, Paris, France; UPRES EA 2397, Universite Pierre et Marie Curie Paris VI, Paris, France
2 UPRES EA 2397, Universite Pierre et Marie Curie Paris VI, Paris, France; Service Central d'Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique - Hopitaux de Paris, Paris, France
3 Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique - Hopitaux de Paris, Paris, France
4 Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie,, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique - Hopitaux de Paris, Paris, France; Servizio di Medicina Interna 1, Spedali Civili, and Universita di Brescia, Brescia, Italy
* To whom correspondence should be addressed. E-mail: thomas.similowski{at}psl.ap-hop-paris.fr.
Repeated inspiratory occlusions in humans elicit respiratory-related cortical potentials, the respiratory counterpart of somatosensory-evoked potentials. These potentials comprise early components (stimulus detection) and late components (cognitive processing). They are considered as the summation of several afferent activities from various part of the respiratory system. This study assesses the role of the upper airway as a determinant of the early and late compotents of the potentials, taking advantage of the presence of a tracheotomy in patients totally or partially deafferented. Eight patients who could breathe either through the mouth or through a tracheotomy orifice (whole upper airway bypassed) were studied (four quadriplegic patients with phrenic pacing, four patients with various sources of inspiratory pump dysfunction). Respiratory-related evoked potentials were recorded in Cz-C3 and Cz-C4. They were consistently present after mouth occlusions, with a first positive P1 and a first negative N1 components of normal latencies (P1: 40.4±6.1ms in Cz-C3; 47.6±7.6ms in Cz-C4; N1: 84.4±27.1ms in Cz-C3 and 90.2±17.4ms in Cz-C4) and amplitudes. Tracheal occlusions did not evoke any cortical activity. Therefore, in patients with inspiratory pump dysfunction, the activation of upper airway afferents is sufficient to produce the early components of the respiratory-related evoked cortical potentials. Per contra, in this setting, pulmonary afferents do not suffice to evoke these components.
This article has been cited by other articles:
|
|
 |
|
  J. Huang, C. L. Marcus, P. Bandla, M. S. Schwartz, M. E. Pepe, J. M. Samuel, H. B. Panitch, R. M. Bradford, Y. P. Mosse, J. M. Maris, et al. Cortical Processing of Respiratory Occlusion Stimuli in Children with Central Hypoventilation Syndrome Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 757 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Davenport, A. D. Martin, Y-L. Chou, and S. Alexander-Miller Respiratory-related evoked potential elicited in tracheostomised lung transplant patients. Eur. Respir. J., August 1, 2006; 28(2): 391 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Redolfi, M. Raux, C. Donzel-Raynaud, C. Morelot-Panzini, M. Zelter, J-P. Derenne, T. Similowski, and C. Straus Effects of upper airway anaesthesia on respiratory-related evoked potentials in humans Eur. Respir. J., December 1, 2005; 26(6): 1097 - 1103. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
