Objective: Chronic hypertriglyceridemia is thought to be atherogenic and is associated with an elevated thrombotic potential, both of which may be improved with aerobic exercise training. Methods and Results: Eight subjects were tested for aerobic capacity, body composition, and postprandial lipemia (PPL), followed by 6-months of exercise training and final testing. Blood samples were obtained for measurement of free fatty acid (FFA), TG, insulin (Ins), and glucose (Glu). Hemostatic variables including factor VII activity (FVIIa), tissue factor pathway inhibitor-factor Xa complex (TFPI/Xa), and plasminogen activator inhibitor-1 (PAI-1) antigen / activity as well as leukocyte tumor necrosis factor- (TNF-) gene expression among 4 subjects. The exercise training was of sufficient intensity to increase aerobic capacity (p < 0.0001) and improve body composition (p = 0.04). There were no differences between tests among PPL responses of FFA, TG, Ins, or Glu, however the mean TG response and fat oxidation rate improved. PAI-1 antigen / activity, FVIIa, TFPI/Xa, and TNF- gene expression were all improved following exercise training after adjusting for confounders. Conclusions: Aerobic exercise training reduces the potential for coagulation, improves fibrinolytic potential, and reduces leukocyte TNF- gene expression following the ingestion of a high fat meal.