In order to quantify the concurrent transduction capabilities of spatially distributed intrinsic cardiac neurons, the activities generated by atrial versus ventricular neurons were recorded simultaneously in 12 anesthetized dogs at baseline and during alterations in the cardiac milieu. Less than 5% of atrial and ventricular neurons responded solely to regional mechanical deformation, doing so in a tightly coupled fashion (cross correlation coefficient r = 0.63). The majority of identified atrial and ventricular neurons transduce multimodal stimuli to display stochastic behaviour. Specifically, ventricular chemosensory inputs modified both populations such that they generated no short-term coherence among their activities (cross correlation coefficient r = 0.21±0.07). Regional ventricular ischemia likewise activated both populations in a non-coupled fashion. Yet discrete chemical activation of atrial neurons modifies ventricular ones. Conclusions: Most atrial and ventricular neurons generate concurrent stochastic activity that is predicated primarily upon cardiac chemo-transduction. As a consequence, they display relative independent short-term reflex control over regional cardiac indices. Over longer scales, functional interdependence is manifest as the result of interganglionic interconnections and descending inputs.