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J Appl Physiol (April 5, 2007). doi:10.1152/japplphysiol.01328.2006
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Submitted on November 22, 2006
Accepted on April 2, 2007

QUANTITATIVE TRAIT LOCI (QTL) ASSOCIATED WITH MAXIMAL EXERCISE ENDURANCE IN MICE

J Timothy Lightfoot1*, Michael J. Turner1, Amy M. Kleinfehn1, Anne E. Jedlicka2, Tomohiro Oshimura3, Jacqui Marzec3, Wesley Gladwell3, Larry J. Leamy4, and Steven R. Kleeberger3

1 Kinesiology, University of North Carolina Charlotte, Charlotte, North Carolina, United States
2 Malaria Research Instittute, Johns Hopkins University, Baltimore, Maryland, United States
3 Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Durham, North Carolina, United States
4 Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, United States

* To whom correspondence should be addressed. E-mail: jtlightf{at}email.uncc.edu.

The role of genetics in the determination of maximal exercise endurance is unclear. Six to nine week old F2 mice (n=99, 60 female, 39 male), derived from an intercross of two inbred strains that had previously been phenotyped as having high maximal exercise endurance (Balb/cJ) and low maximal exercise endurance (DBA/2J), were treadmill tested to estimate exercise endurance. Selective genotyping of the F2 cohort (n = 12 high exercise endurance; n = 12 low exercise endurance) identified a significant quantitative trait locus (QTL) on chromosome X (53.7 cM, DXMit121) in the entire cohort and a suggestive QTL on chromosome 8 (36.1 cM, D8Mit359) in the female mice. Fine-mapping with the entire F2 cohort and additional informative markers confirmed and narrowed the QTLs. The chromosome 8 QTL (EE8F) is homologous with two suggestive human QTLs and one significant rat QTL previously linked with exercise endurance. No effect of gender (p=0.33) or body weight (p=0.79) on exercise endurance was found in the F2 cohort. These data indicate that genetic factors in distinct chromosomal regions may affect maximal exercise endurance in the inbred mouse. Whereas multiple genes are located in the identified QTL that could functionally affect exercise endurance, this study serves as a foundation for further investigations delineating the identity of genetic factors influencing maximum exercise endurance.




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