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J Appl Physiol (May 3, 2002). doi:10.1152/japplphysiol.01274.2001
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Articles in PresS, published online ahead of print May 3, 2002
J Appl Physiol, 10.1152/jap.01274.2001
Submitted on January 2, 2002
Accepted on April 30, 2002

TIME DEPENDENCE OF RECRUITMENT AND DERECRUITMENT IN THE LUNG: A THEORETICAL MODEL

Jason H.T. Bates1* and Charles G. Irvin1

1 Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, VT, USA

* To whom correspondence should be addressed. E-mail: jhtbates{at}zoo.uvm.edu.

Recruitment and derecruitment (R/D) of airspaces within the lung is greatly enhanced in lung injury, and is thought to be responsible for exacerbating injury during mechanical ventilation. There is evidence to suggest that R/D is a time-dependent phenomenon. We have developed a computer model of the lung consisting of a parallel arrangement of airways and alveolar units. Each airway has a critical pressure (Pcrit) above which it tends to open and below which it tends to close, but at a rate determined by how far pressure is from Pcrit. With an appropriate distribution of Pcrit and R/D velocity characteristics, the model able to produce realistic first and second pressure-volume curves of a lung inflated from an initially degassed state. The model also predicts that lung elastance will increase transiently following a deep inflation, to a degree that increases as lung volume decreases and as the lung becomes injured. We conclude that our model captures the time-dependent mechanical behavior of the lung due to gradual R/D of lung units.




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