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Articles in PresS, published online ahead of print May 10, 2002
J Appl Physiol, 10.1152/jap.01271.2001
Submitted on December 31, 2001
Accepted on May 5, 2002
1 Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
* To whom correspondence should be addressed. E-mail: malin.rohdin{at}fyfa.ki.se.
In normal gravity, lung diffusing capacity (D) and lung tissue volume (LTV, including pulmonary-capillary blood volume) change in concert, for example during shifts between upright and supine. Accordingly, D and LTV might be expected to decrease together in sitting subjects in hypergravity due to peripheral pooling of blood and reduced central blood volume. Nine sitting subjects in a human centrifuge were exposed to 1, 2 and 3 times increased gravity in the head-to-feet direction (Gz+) and rebreathed a gas containing trace amounts of acetylene and carbon monoxide. D was 25.2 ± 2.6, 20.0 ± 2.1, and 16.7 ± 1.7 ml*min-1*mbar-1 (mean ± SEM) at 1, 2 and 3 Gz+, respectively (ANOVA P<0.001). Corresponding values for LTV increased from 541 ± 34 to 677 ± 43, and 756 ± 71 ml (P<0.001) at 2 and 3 Gz+. Results are compatible with sequestration of blood in the dependent part of the pulmonary circulation just as in the systemic counterpart. D which under normoxic conditions is mainly determined by its membrane component, decreased despite an increased pulmonary-capillary blood volume, most likely as a consequence of a less homogenous distribution of alveolar volume with respect to pulmonary-capillary blood volume.
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