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J Appl Physiol (January 18, 2002). doi:10.1152/japplphysiol.01263.2001
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Articles in PresS, published online ahead of print January 18, 2002
J Appl Physiol, 10.1152/jap.01263.2001
Submitted on December 27, 2001
Accepted on January 17, 2002

ENHANCED PLASMA IL-6 AND IL-1ra RESPONSES TO REPEATED VERSUS SINGLE BOUT OF PROLONGED CYCLING IN ENDURANCE ATHLETES

Ola Ronsen1*, Tor E Lea2, Roald Bahr3, and Bente Klarlund Pedersen4

1 Department of Sports Medicine, Norwegian Olympic Sports Center, Oslo, Norway
2 Department of Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
3 Department of Health Science, Norwegian University of Sports and Physical Education, Oslo, Norway
4 Department of Copenhagen Muscle Research Center, Rigshospitalet University Hospital, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: ola.ronsen{at}olympiatoppen.no.

The impact of repeated bouts of exercise on plasma levels of interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1ra) was examined. Nine well-trained men participated in four different 24h trials: LONG: two bouts of exercise (Ex-M1 and Ex-A) separated by 6h; SHORT: two bouts (Ex-M2 and Ex-A) separated by 3h; ONE: single bout performed at the same time in the afternoon as second bout (Ex-A) in prior trials; REST: no exercise. All exercise bouts were performed on a cycle-ergometer at 75% of VO2max, lasting 75 min. Peak IL-6 observed at the end of Ex-A was significantly higher in SHORT (8.8 ± 1.3pg/ml) than ONE (5.2 ± 0.7pg/ml), but not compared with LONG (5.9 ± 1.2 pg/ml). Peak IL-1ra observed 1h post-exercise was significantly higher in SHORT (1774 ± 373pg/ml) than ONE (302 ± 53pg/ml), but not compared with LONG (1276 ± 451pg/ml). We conclude that when a second bout of endurance exercise is performed after only 3h of recovery, IL-6 and IL-1ra responses are elevated. This may be linked to muscle glycogen depletion.




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