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J Appl Physiol (April 5, 2002). doi:10.1152/japplphysiol.01250.2001
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Articles in PresS, published online ahead of print April 5, 2002
J Appl Physiol, 10.1152/jap.01250.2001
Submitted on December 21, 2001
Accepted on March 28, 2002

Altered Frequency Responses of Sympathetic Nerve Discharge Bursts After Interleukin-1ß and Mild Hypothermia

Michael J Kenney1*, Frank Blecha1, Richard J Fels1, and Donald A Morgan2

1 Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA
2 Department of Internal Medicine, University of Iowa, Iowa City, IA, USA

* To whom correspondence should be addressed. E-mail: kenny{at}vet.ksu.edu.

Although interleukin-1ß (IL-1ß) administration produces nonuniform changes in the level of sympathetic nerve discharge (SND), the effect of IL-1ß on the frequency-domain relationships between discharges in different sympathetic nerves is not known. Autospectral and coherence analyses were used to determine the effect of IL-1ß and mild hypothermia (60 min after IL-1ß, Tc from 38°C to 36°C) on the relationships between renal-interscapular brown tissue (IBAT) and splenic-lumbar sympathetic nerve discharges in chloralose-anesthetized rats. The following observations were made: 1) IL-1ß did not alter renal-IBAT coherence values in the 0- to 2-Hz frequency band or at the cardiac frequency (CF). 2) Peak coherence values relating splenic-lumbar discharges at the CF were significantly increased after IL-1ß and during hypothermia. 3) Hypothermia after IL-1ß significantly reduced the coupling (0-2 Hz and CF) between renal-IBAT but not splenic-lumbar SND bursts. 4) Combining IL-1ß and mild hypothermia had a greater effect on renal-IBAT SND coherence values than did mild hypothermia alone. These data demonstrate functional plasticity in sympathetic neural circuits and suggest complex relationships between immune products and SND regulation.






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