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Articles in PresS, published online ahead of print February 19, 2002
J Appl Physiol, 10.1152/jap.01248.2001
Submitted on December 21, 2001
Accepted on January 25, 2002
1 Dipartimento di Scienze Motorie e Riabilitative, Universita di Genova, Genoa, Italy
2 Fisiopatologia Respiratoria, Azienda Ospedaliera S Croce e Carlerle Cuneo, Cuneo, Italy
3 Dipartimento di Medicina Interna, Universita di Genova, Genoa, Italy
* To whom correspondence should be addressed. E-mail: brusasco{at}dism.unige.it, oftedahl.lynette@mayo.edu.
We studied whether bronchodilatation occurs with exercise during late asthmatic reaction to allergen (LAR; group 1, n=13) or natural asthma (NA; group 2, n=8) and it is sufficient to preserve maximum ventilation (VEMAX), oxygen consumption (VO2MAX), and exercise performance (WMAX). In group 1, partial forced expiratory flow at 30% of resting FVC (Vpart30) increased with exercise both at control and during LAR. WMAX was slightly reduced during LAR, whileVEMAX, tidal volume (VT), breathing frequency (BF), and VO2MAX were preserved. At WMAX, functional residual capacity (FRC) and end-inspiratory lung volume were significantly larger during LAR than at control. In group 2, Vpart30 increased with exercise during NA but did not attain the control values after appropriate therapy. WMAX was slightly reduced during NA, while VO2MAX and VEMAX were preserved. At WMAX, FRC was significantly larger during NA than at control, while VT decreased and BF increased. In conclusion, bronchodilation occurs with exercise during either LAR or NA, allowing 
EMAX and VO2MAX to be preserved with small changes in breathing pattern and slight reduction in WMAX.
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