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Articles in PresS, published online ahead of print March 1, 2002
J Appl Physiol, 10.1152/jap.01239.2001
Submitted on December 18, 2001
Accepted on February 25, 2002
1 Department of Human Studies, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
2 Department of Diagnostic and Theraputic Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
3 Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
4 Physical Therapy Program, The University of Finley, Findley, Ohio, USA
5 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
6 Laval Hospital Research Center, Division of Kinesiology, Laval University, Quebec City, Quebec, Canada
7 Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA
* To whom correspondence should be addressed. E-mail: ghunter{at}uab.edu.
The purpose of this study was to determine whether muscle metabolic capacity was inversely related to age after adjusting for physical activity in sedentary premenopausal women. Eighty-three women (ages 23-47) had free living activity related energy expenditure (AEE) evaluated using doubly labeled water procedures and room calorimeter determined sleeping energy expenditure. VO2 max and strength were evaluated in all subjects, while 31P magnetic resonance spectroscopy (31P MRS) determined metabolic economy during maximal exercise and muscle biopsy maximal enzyme activity were evaluated in subsets of the sample (48 and 18 subjects respectively). Age was significantly related to whole body treadmill endurance time (r = -0.32), plantar flexion strength (r = -0.29), VO2 max (r = -0.27), 31P MRS ADP recovery rate (r = -0.44) and anaerobic glycolytic capacity (r = -0.37), and muscle biopsy citrate synthase activity (r = -0.48), glyceraldehyde 3 phosphate dehydrogenase (r = -0.54), phosphofructokinase (r = -0.62), and phosphorylase (r = -0.58) activity even after adjusting for AEE. These data suggest that in sedentary premenopausal women, both oxidative and glycolytic muscle capacity decrease with age even when taking into account physical activity.
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