| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
coactivator-1
improves exercise performance and increases peak oxygen uptake
1 Diabetes and Metabolism, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States
2 Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, United States
3 Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States; Cell Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States
4 Cell Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States
* To whom correspondence should be addressed. E-mail: shamina.rangwala{at}novartis.com.
The induction of peroxisome proliferator-activated receptor 
coactivator 1 
(PGC-1 ), a key regulator of mitochondriogenesis, is well-established under multiple physical exercise regimens including, endurance, resistance, and sprint training. We wanted to determine if increased expression of PGC-1 in muscle is sufficient to improve performance during exercise in vivo. We demonstrate that muscle-specific expression of PGC-1 improves the performance during voluntary as well as forced exercise challenges. Additionally, PGC-1 transgenic mice exhibit an enhanced performance during a peak VO2 exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake. This increased ability to perform in multiple exercise paradigms is supported by enhanced mitochondrial function as suggested by increased mitochondrial gene expression, mitochondrial DNA, and mitochondrial enzyme activity. Thus, this study demonstrates that upregulation of PGC-1 in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake.
This article has been cited by other articles:
|
|
 |
|
  K. J. Cureton, P. D. Tomporowski, A. Singhal, J. D. Pasley, K. A. Bigelman, K. Lambourne, J. L. Trilk, K. K. McCully, M. J. Arnaud, and Q. Zhao Dietary quercetin supplementation is not ergogenic in untrained men J Appl Physiol, October 1, 2009; 107(4): 1095 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Park, P.-y. Wang, T. Matsumoto, H. J. Sung, W. Ma, J. W. Choi, S. A. Anderson, S. C. Leary, R. S. Balaban, J.-G. Kang, et al. p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content Circ. Res., September 25, 2009; 105(7): 705 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Yang, M. H. Vitaterna, A. D. Laposky, K. Shimomura, and F. W. Turek Genetic analysis of daily physical activity using a mouse chromosome substitution strain Physiol Genomics, September 1, 2009; 39(1): 47 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Adhihetty, G. Uguccioni, L. Leick, J. Hidalgo, H. Pilegaard, and D. A. Hood The role of PGC-1{alpha} on mitochondrial function and apoptotic susceptibility in muscle Am J Physiol Cell Physiol, July 1, 2009; 297(1): C217 - C225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Davis, E. A. Murphy, M. D. Carmichael, and B. Davis Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1071 - R1077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Haramizu, A. Nagasawa, N. Ota, T. Hase, I. Tokimitsu, and T. Murase Different contribution of muscle and liver lipid metabolism to endurance capacity and obesity susceptibility of mice J Appl Physiol, March 1, 2009; 106(3): 871 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lippi, U. G. Longo, and N. Maffulli Genetics and sports Br. Med. Bull., February 9, 2009; (2009) ldp007v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Pilegaard and E. A. Richter PGC-1{alpha}: important for exercise performance? J Appl Physiol, May 1, 2008; 104(5): 1264 - 1265. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
