Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol (May 31, 2002). doi:10.1152/japplphysiol.01221.2001
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Articles in PresS, published online ahead of print May 31, 2002
J Appl Physiol, 10.1152/jap.01221.2001
Submitted on December 12, 2001
Accepted on May 30, 2002

Effects of Tower Climbing Exercise on Bone Mass, Strength and Turnover in Orchidectomized Growing Rats

Takuya Notomi1, Yuichi Okazaki2, Nobukazu Okimoto2, Yuri Tanaka1, Toshitaka Nakamura2, and Masashige Suzuki1*

1 Institute of Health & Sport Sciences, University of Tsukuba, Tsukuba, Ibaragi, Japan
2 Department of Orthopedic Surgery, University of Occupational and Enviromental Health, Kitakyusyu, Fukuoka, Japan

* To whom correspondence should be addressed. E-mail: msuzuki{at}taiiku.tsukuba.ac.jp.

To determine the effects of a tower climbing exercise on mass, strength and local turnover of bone, 70 9-week-old Sprague Dawley rats were assigned to seven groups: a baseline control and three groups of sham-operated sedentary, orchidectomized (ORX)-sedentary and ORX-exercise rats. Rats voluntarily climbed a 200 cm tower to drink water from a bottle set at the top. At 4 weeks, the periosteal bone formation rate (BFR/BS), moment of inertia, bone mineral content (BMC), bone mineral density (BMD) and bending load at the midfemur were maintained in ORX-exercise rats, whereas these parameters were reduced in ORX-sedentary rats. At 8 weeks, the periosteal mineral apposition rate (MAR) and BFR/BS in ORX-exercise rats were significantly higher, while the parameters in ORX-sedentary rats did not differ, compared to the sham-sedentary rats. In ORX-exercise rats, the trabecular mineralizing surface (MS/BS), BFR/BS and bone volume (BV/TV) of the lumbar vertebrae were maintained at the same levels as those in the sham-sedentary group, while the osteoclast surface (Oc.S/BS) decreased compared to the ORX-sedentary group. However, the climbing exercise did not affect BMC, BMD or the compression load of the lumbar vertebrae. These results show that in the midfemur the voluntary climbing exercise maintained cortical bone mass and strength by stimulating periosteal bone formation, and partially prevented ORX-induced trabecular bone loss, depressing the elevation of turnover. Interestingly, in ORX rats, the climbing exercise had the opposite effect on bone formation at the periosteal femoral cortical bone, where the exercise increased the bone formation, as compared to vertebral trabecular bone where the exercise decreased it.






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