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J Appl Physiol (May 3, 2002). doi:10.1152/japplphysiol.01214.2001
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Articles in PresS, published online ahead of print May 3, 2002
J Appl Physiol, 10.1152/jap.01214.2001
Submitted on December 10, 2001
Accepted on April 25, 2002

The exercise-induced change in Type 1 cytokine-producing CD8+ T cells is related to a decrease in memory T cells

Tobias Ibfelt1, Emil Wolsk Petersen1, Helle Bruunsgaard2, Marie Sandmand2, and Bente Klarlund Pedersen1*

1 The Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark; The Copenhagen Muscle Research Centre Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
2 The Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: bkp{at}rh.dk.

In response to exercise, both CD4+ and CD8+ T cells are mobilised to the blood, but the levels of these cells decline below pre-values in the post-exercise period. T cells are functionally polarised depending on the cytokines they produce. Type 1 cells produce e.g. interferon-{gamma}, whereas type 2 produce e.g. interleukin (IL)-4. It was recently demonstrated that exercise induces a decrease in the percentage of type 1 T cells. The present study further investigated the mechanisms underlying the exercise-induced shift in the balance between type 1 and type 2 cytokine producing cells. Seven healthy males performed 1.5 hours of treadmill running with blood samples drawn before, in the end, and 2 hours after exercise. Intracellular expression of IFN-{gamma}, IL-2 and IL-4 was detected in CD4+ and CD8+ T cells following stimulation with PMA and ionomycin. Intracellular expression of IFN-{gamma} within CD8+ cells was decreased in the post-exercise period compared to values obtained immediately after exercise, whereas the expression of IL-2 and IL-4 did not change within the CD4+ and CD8+ cell populations. The decrease in IFN-{gamma} producing CD8+ T cells post-exercise was negatively correlated with a decrease in percentage memory T cells within the CD8+ cells (r= -0.94; p<=0.002). In conclusion, this study demonstrates that the exercise-induced change in type 1 cytokine producing T cells is related to a decline in memory cells.




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