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1 Dept. of Anesthesiology, University of Luebeck, Luebeck, Germany
2 Institute of Physiology, University of Luebeck, Luebeck, Germany
3 Institute of Clinical Biochemistry, University of Oslo, Oslo, Norway
4 Immundiagnostik AG, Bensheim, Germany
* To whom correspondence should be addressed. E-mail: Heringlake{at}t-online.de.
The polypeptide relaxin (RLX) has been suggested to play a role in cardio-renal integration and to be related to the natriuretic peptide system. We hence examined the effects of variations in thoracic-blood-volume (TBV) and intravenous volume-loading on plasma- and urinary RLX-levels and associated changes in natriuretic peptide levels in healthy males. Two groups of eight subjects were randomly tilted into a 15°-feet-down (FD) or a 15°-head-down (HD) position. Ten volunteers were cross-over subjected to an infusion of 15 ml*kg-1 NaCl 0.9% (over 60 min) or control during an observation period of 10 hours. Blood and urine was sampled at timed intervals. RLX, N-terminal proANP (NTproANP), and N-terminal proBNP (NTproBNP) were determined by enzyme-, radio-, and electrochemoluminiscence immunoassays, respectively. NTproANP levels (in % of baseline levels) were higher (p<0.05) during HD (124±13%) than during FD (82±6%;). NTproBNP and RLX were not affected by tilting. Volume-loading induced a short lasting increase in plasma-NTproANP, a delayed increase in plasma NTproBNP, had no effect on plasma RLX, and induced a parallel increase in urine flow, renal excretion of sodium, RLX, and NTproBNP. It is concluded that variations in TBV in healthy males are not associated with variations in plasma RLX. Increased urinary RLX and NTproBNP excretion during volume-loading suggest renal production and a possible role of kidney-derived RLX and BNP in sodium homeostasis in men.
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