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J Appl Physiol (February 15, 2002). doi:10.1152/japplphysiol.01196.2001
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Articles in PresS, published online ahead of print February 15, 2002
J Appl Physiol, 10.1152/jap.01196.2001
Submitted on December 4, 2001
Accepted on February 8, 2002

The angiotensin-converting enzyme gene and physical activity, blood pressure and hypertension. A population study in Finland

Ricardo M Fuentes1*, Markus Perola2, Aulikki Nissinen2, and Jaakko Tuomilehto3

1 Department of Public Health and General Practice, University of Kuopio, Faculty of Medicine, Kuopio, Kuopio, Finland
2 Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Helsinki, Finland
3 Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Helsinki, Finland; Department of Public Health, University of Helsinki, Helsinki, Helsinki, Finland

* To whom correspondence should be addressed. E-mail: ricardo.fuentes{at}messi.uku.fi.

The study evaluated the association of the insertion/deletion polymorphism of the angiotensin converting enzyme gene (ACE I/D) with self-reported moderate intensity leisure time physical activity (MILTPA), arterial blood pressure (BP) and history of hypertension (HT). A representative population-based sample of 721 middle-aged adults (358 women) from two areas of Finland was genotyped for the ACE I/D. After exclusion criteria were applied 455 subjects (288 women) were selected for the analysis.The distribution of the ACE I/D genotypes did not differ significantly among frequent/non-frequent MILTPA groups (X2 = 2,556; df = 2; p-value = 0,279). The main predictors of BP were male gender, age, BMI and arterial pulse. Additionally, tobacco smoking and alcohol consumption also had a significant main effect on DBP. HT was significantly more frequent in subjects with obesity, family history of CVD or lower educational level. As for BP, neither ACE I/D nor MILTPA was associated with HT. The study confirmed recent reports from population-based studies of no association between ACE I/D and physical fitness. The study also confirmed a lack of association between ACE I/D and BP or HT.




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