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Articles in PresS, published online ahead of print November 9, 2001
J Appl Physiol, 10.1152/jap.01194.2000
Submitted on December 13, 2000
Accepted on October 29, 2001
1 Heart-Lung dept, Goteborg University, Goteborg, Sweden
2 Heart -Lung dept, Goteborg University, Goteborg, Sweden
3 Internal medicin, Goteborg University, Goteborg, Sweden
* To whom correspondence should be addressed. E-mail: peter.lonnroth{at}vgregion.se.
To evaluate the effect of passive muscle shortening and lengthening (PSL) on the transcapillary exchange of glucose, lactate, and insulin in the insulin stimulated state, microdialysis was performed in rat quadriceps muscle. Electrical pulsative stimulation (0.1 msec, 0.3-0.6 V, 1 Hz) was performed on the sciatic nerve in one leg to induce passive tension on the quadriceps during a hyperinsulinemic euglycemic clamp (10 mU/kg/min). In the non-insulin-stimulated state (basal state) the muscle arterial-interstitial (A-I) concentration difference of glucose was 1.6±0.3 mM (p<0.01). During insulin infusion, it remained unaltered in resting muscle (1.3±0.3 mM), but diminished during PSL. In the basal state, no I-A difference of lactate was present whereas in the insulin infusion state it increased significantly and was significantly larger in moving (2.8±0.5 mM, p<0.01) relative to resting muscle (0.7±0.4 mM). The A-I concentration difference of insulin was equal in resting (86±7 µU/mL) and moving muscle (100±8 µU/mL). Muscle blood flow estimated by using radiolabelled microspheres was 17±4 ml/100g/min and increased to 34±6 ml/100g/min (p<0.05) during PSL. These results confirm that diffusion over the capillary wall is partly rate-limiting for the exchange of insulin and glucose and lactate in resting muscle. PSL, in addition to insulin stimulation, increases blood flow and capillary permeability and, as a result, diminishes the A-I-concentration gradient of glucose but not that of insulin or lactate.
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