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1 Department of Medicine, University of Vermont, Burlington, VT, USA
2 Department of Neurology, University of Vermont, Burlington, VT, USA; Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT, USA
3 Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT, USA
* To whom correspondence should be addressed. E-mail: richard.galbraith{at}uvm.edu.
Administration of cobaltic protoporphyrin IX (CoPP) into the III ventricle of the brain by intracerebroventricular (icv) injection in rodents is known to result in transient hypophagia and remarkably prolonged weight loss. The mechanism of action of CoPP in eliciting these effects is unknown. It is known that nitric oxide plays a role in food intake and that the hyperphagia that results from a wide variety of genetic, physiological and pharmacological stimuli can be blocked by the administration of inhibitors of the enzyme nitric oxide synthase (NOS). We demonstrate that icv administration of compounds which alter nitrergic tone can also change food ingestion and weight gain patterns in normophagic rats. We also demonstrate that CoPP decreases NOS activity, but paradoxically increases nNOS transcript expression and increases nNOS protein content on Western Blotting.
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