Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (April 16, 2004). doi:10.1152/japplphysiol.01169.2003
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
97/3/806    most recent
01169.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WU, J.
Right arrow Articles by ISHIMI, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WU, J.
Right arrow Articles by ISHIMI, Y.
Submitted on October 31, 2003
Accepted on April 12, 2004

High Bone Mass Gained By Exercise in the Growing Male Mice Is Increased By Subsequent Reduced Exercise

JIAN WU1, XIN XIANG WANG1, MITSURU HIGUCHI2, KAZUHIKO YAMADA1, and YOSHIKO ISHIMI1*

1 Division of Applied Food Research, The National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan
2 Division of Health Promotion, The National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan; School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan

* To whom correspondence should be addressed. E-mail: ishimi{at}nih.go.jp.

Exercise-induced bone gains are lost if exercise ceases. Therefore, continued exercise at a reduced frequency or intensity may be required to maintain these benefits. In this study, we evaluated whether or not 4 weeks of reduced exercise after 4 weeks of running exercise in growing male mice results in the maintenance of high bone mass. Five week-old mice were divided into the following groups; 1) Baseline control; 2) 4-week control; 3) 4-week exercise; 4) 8-week control; 5) 4-week exercise followed by 4-week cessation of training; and 6) 4-week exercise followed by reduced exercise at 1/2 the frequency. The regimen consisted of exercise 6-days/week, and the reduced exercise regimen consisted of running 3-days/week on a treadmill for 30min/day, at 12m/min on a 10°uphill slope. Running exercise significantly increased bone mineral density (BMD) of the femur, periosteal mineral apposition rate (MAR), bone formation rate (BFR/BS) and percent labeled perimeter at the midfemur, and osteogenic activity of bone marrow cells. However, these parameters declined to the age-matched sedentary control after cessation of training. In contrast, the reduced exercise group had significantly higher MAR compared with those of the sedentary control and cessation of training groups. Furthermore, BMD for the reduced exercise group was significantly higher than those for the other groups. These results suggest that the high bone formation gained through exercise can be maintained, and bone mass was further increased by subsequent exercise even if the exercise frequency is reduced.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Honda, N. Sogo, S. Nagasawa, T. Kato, and Y. Umemura
Bones benefits gained by jump training are preserved after detraining in young and adult rats
J Appl Physiol, September 1, 2008; 105(3): 849 - 853.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
P Zhang, G M Malacinski, and H Yokota
Joint loading modality: its application to bone formation and fracture healing
Br. J. Sports Med., July 1, 2008; 42(7): 556 - 560.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. J. Rogers, D. Berrigan, D. A. Zaharoff, K. W. Hance, A. C. Patel, S. N. Perkins, J. Schlom, J. W. Greiner, and S. D. Hursting
Energy Restriction and Exercise Differentially Enhance Components of Systemic and Mucosal Immunity in Mice
J. Nutr., January 1, 2008; 138(1): 115 - 122.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
K. J. Carlson and S. Judex
Increased non-linear locomotion alters diaphyseal bone shape
J. Exp. Biol., September 1, 2007; 210(17): 3117 - 3125.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.