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J Appl Physiol (February 8, 2007). doi:10.1152/japplphysiol.01165.2006
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Submitted on October 16, 2006
Accepted on February 6, 2007

IGF-II Gene Region Polymorphisms Related to Exertional Muscle Damage

Joseph Michael Devaney1, Eric P. Hoffman1, Heather Gordish-Dressman1, Amy Kearns2, Edward Zambraski3, and Priscilla M Clarkson2*

1 Research Center for Genetic Medicine, Children's National Medical Center, Washington, District of Columbia, United States
2 Department of Exercise Science, University of Massachusetts, Amherst, Massachusetts, United States
3 United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States

* To whom correspondence should be addressed. E-mail: clarkson{at}kin.umass.edu.

We examined the association of a novel SNP in IFG-I (IGF-I -C1245T located in the promoter) and eight SNPs in the IGF-II gene region with indicators of muscle damage (strength loss, muscle soreness, and increases in circulating levels of creatine kinase [CK] and myoglobin) after eccentric exercise. We also examined 2 SNPs in the IGF binding protein-3 (IGFBP-3). The age, height and body mass of the 151 subjects studied were 24.1 ± 5.2, 170.8 ±9.9 cm, and 73.3 ± 17.0 kg, respectively. There were no significant associations of phenotypes with IGF-I. IGF-II SNP (G12655A, rs3213216) and IGFBP-3 SNP (A8618T, rs6670) were not significantly associated with any variable. The most significant finding in this study was that for men, IGF-II (C13790G, rs3213221), IGF-II (ApaI, G17200A, rs680), IGF2AS (G11711T, rs7924316), and IGFBP-3 (-C1592A, rs2132570) were significantly associated with muscle damage indicators. We found that men: 1) homozygous for the rare IGF-II C13790G allele and rare allele for the ApaI (G17200A) SNP, demonstrated the greatest strength loss immediately after exercise, greatest soreness and highest post-exercise serum CK activity; 2) homozygous wildtype for IGF2AS (G11711T, rs7924316) had the greatest strength loss and most muscle soreness; 3) homozygous wildtype for the IGF2AS G11711T SNP showed the greatest strength loss, highest muscle soreness, and greater CK and myoglobin response to exercise. In women, fewer significant associations appeared.




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