Journal of Applied Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (January 4, 2002). doi:10.1152/japplphysiol.01155.2001
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/5/1865    most recent
01155.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, L.
Right arrow Articles by Seow, C. Y
Right arrow Search for Related Content
PubMed
Right arrow Articles by Wang, L.
Right arrow Articles by Seow, C. Y

Articles in PresS, published online ahead of print January 4, 2002
J Appl Physiol, 10.1152/jap.01155.2001
Submitted on November 21, 2001
Accepted on January 2, 2002

Changes in force-velocity properties of trachealis due to oscillatory strains

Lu Wang1, Peter D Pare1, and Chun Y Seow2*

1 Medicine, University of British Columbia, Vancouver, BC, Canada; McDonald Research Laboratories / The iCapture Center, University of British Columbia, Vancouver, BC, Canada
2 Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; McDonald Research Laboratories / The iCapture Center, University of British Columbia, Vancouver, BC, Canada

* To whom correspondence should be addressed. E-mail: cseow{at}interchange.ubc.ca.

The physically dynamic environment of the lung constantly modulates the mechanical properties of airway smooth muscle. In vitro experiments have shown that contractility of the muscle is compromised by oscillatory strains, perhaps through disruption of crossbridge interaction and organization of the contractile filaments. To understand the mechanism by which oscillation affects contractility, functional changes of the muscle in terms of force-velocity relationship were assessed before and after imposition of length oscillation in both relaxed and activated states. The oscillation protocol was designed to reduce isometric force by 15-20%, followed by measurement of force-velocity properties. Maximal velocity and power changed by +8% and -14% respectively after oscillation applied in the relaxed state and changed by -15% and -25% respectively after oscillation applied during contraction. A simple model of reduced activation could not account for the results; neither could the results be explained satisfactorily by the current crossbridge theory of contraction. The results however could be explained if the possibility of reorganization of the contractile filaments due to oscillatory strains was considered.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. H. T. Bates, S. R. Bullimore, A. Z. Politi, J. Sneyd, R. C. Anafi, and A. -M. Lauzon
Transient oscillatory force-length behavior of activated airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, August 1, 2009; 297(2): L362 - L372.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Xue, L. Zhang, Y. Liu, S. J. Gunst, and R. S. Tepper
Chronic inflation of ferret lungs with CPAP reduces airway smooth muscle contractility in vivo and in vitro
J Appl Physiol, March 1, 2008; 104(3): 610 - 615.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Xue, L. Zhang, R. Ramchandani, Y. Liu, V. B. Antony, S. J. Gunst, and R. S. Tepper
Respiratory system responsiveness in rabbits in vivo is reduced by prolonged continuous positive airway pressure
J Appl Physiol, August 1, 2005; 99(2): 677 - 682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. Herrera, E. C. Martinez, and C. Y. Seow
Electron microscopic study of actin polymerization in airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1161 - L1168.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Lambert, P. D. Pare, and C. Y. Seow
Mathematical description of geometric and kinematic aspects of smooth muscle plasticity and some related morphometrics
J Appl Physiol, February 1, 2004; 96(2): 469 - 476.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. C. Henderson, E. P. Ingenito, H. Atileh, E. Israel, B. Suki, and K. R. Lutchen
Selected Contribution: How does airway inflammation modulate asthmatic airway constriction? An antigen challenge study
J Appl Physiol, August 1, 2003; 95(2): 873 - 882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K.-H. Kuo, A. M. Herrera, L. Wang, P. D. Pare, L. E. Ford, N. L. Stephens, and C. Y. Seow
Structure-function correlation in airway smooth muscle adapted to different lengths
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C384 - C390.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. E. McParland, P. T. Macklem, and P. D. Pare
Airway wall remodeling: friend or foe?
J Appl Physiol, July 1, 2003; 95(1): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Wang, B. E. McParland, and P. D. Pare
The Functional Consequences of Structural Changes in the Airways: Implications for Airway Hyperresponsiveness in Asthma
Chest, March 1, 2003; 123 (2009): 356S - 362S.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.