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Articles in PresS, published online ahead of print February 8, 2002
J Appl Physiol, 10.1152/jap.01153.2001
Submitted on November 21, 2001
Accepted on February 5, 2002
1 Department of Physiology & Biophysics, University of California, Irvine, CA, USA
* To whom correspondence should be addressed. E-mail: gradams{at}uci.edu.
Training protocols apply sequential bouts of resistance exercise (RE) to induce the cellular and molecular responses necessary to produce compensatory hypertrophy. This study was designed to: 1) define the time course of selected cellular and molecular responses to a single bout of RE; 2) examine the effects of inter-bout rest intervals on the summation of these responses. Rat muscles were exposed to RE via stimulation of the sciatic nerve in vivo. Stimulated and control muscles were obtained a various time points post RE and analyzed via Western blot and RT-PCR. A single bout of RE increased intracellular signaling (i.e., phosphorylations) and expression of mRNAs for IGF-I system components and myogenic markers (e.g., cyclin D1, myogenin). A rest interval of 48 hrs between RE bouts resulted in much greater summation of myogenic responses than 24 or 8 hr rest intervals. This experimental approach should be useful for studying the regulatory mechanisms which control the hypertrophy response. These methods could also be used to compare and contrast different exercise parameters (e.g., concentric vs. eccentric, etc.).
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