Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol (February 7, 2003). doi:10.1152/japplphysiol.01127.2002
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Submitted on December 6, 2002
Accepted on February 4, 2003

Temporal Association of Nitric Oxide Levels and Airflow In Asthma after Whole Lung Allergen Challenge

Sumita B Khatri1, Jeffery Hammel2, Mani S Kavuru1, Serpil C Erzurum3, and Raed A Dweik1*

1 Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
2 Biostatistics, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
3 Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Cancer Biology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

* To whom correspondence should be addressed. E-mail: dweikr{at}ccf.org.

Exhaled nitric oxide (NO) levels are high in asthmatics and increase with exacerbations. We hypothesized that higher levels of NO observed during asthma exacerbations are due to increased synthesis of NO. Exhaled NO and peak flows were measured in 11 asthmatics 9 healthy controls before and following experimental asthmatic response induced by whole lung allergen challenge. Baseline peak flows of asthmatics were significantly lower than controls and decreased significantly immediately after challenge (p=0.004). NO was measured by collecting exhaled breaths without breath hold [NO0] and following a 15 second breath hold [NO15]. The rate of NO accumulation over time (ppb/sec) was calculated by {Delta}NO/{Delta}t = [NO15 - NO0] / 15. The NO accumulation rate in asthma and controls were similar at baseline, however NO accumulation at 24 hr increased 3-fold from baseline in asthmatics compared to controls [asthmatics, 0.6±0.2 ppb/s, controls, 0.2±0.1 ppb/s; p=0.01]. Our study suggests that increased NO during an asthma exacerbation is due to increased synthesis, perhaps by increased expression of NO synthases.




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