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1 Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
2 Centre for Child Health Research, University of Western Australia, Perth, WA, Australia; Medical Informatics and Engineering, University of Szeged, Szeged, Hungary
* To whom correspondence should be addressed. E-mail: lizb{at}ichr.uwa.edu.au.
Most studies using mice to model human lung diseases are carried out in adults, although there is emerging interest in the effects of allergen, bacterial and viral exposure early in life. This study aims to characterize lung function in Balb/c mice from infancy (2 wk) through to adulthood (8 wk). The low-frequency forced oscillation technique was used to obtain impedance data, partitioned into components representing airways resistance (Raw), tissue damping (G), tissue elastance (H) and hysteresivity (G/H). Measurements were made at end expiratory pause (trans-respiratory system pressure (Prs)=2 cmH2O) and during relaxed slow expiration from 20 to 0 cmH2O. Raw decreased with age from 0.63 cmH2O.s.ml-1 at 2 wk to 0.24 cmH2O.s.ml-1 at 8 wk (p<0.001). Both G and H decreased with age (p<0.001) from 2 wk to 5 wk, then plateaued through to 8 wk (p<0.001). This pattern was seen both in measurements taken at end expiratory pause and during expiration. There were no age-related changes seen in hysteresivity when measured at end expiratory pause but the pattern of volume dependence did differ with the age of the mice. These changes in respiratory mechanics parallel the reported structural changes of the murine lung from the postnatal period into adulthood.
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