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J Appl Physiol (December 15, 2005). doi:10.1152/japplphysiol.01105.2005
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Submitted on September 8, 2005
Accepted on December 12, 2005

NITRIC OXIDE REGULATION OF MICROVASCULAR OXYGEN EXCHANGE DURING HYPOXIA AND HYPEROXIA

Pedro Cabrales1*, Amy G. Tsai2, and Marcos Intaglietta2

1 La Jolla Bioengineering Institute, La Jolla, CA, USA
2 La Jolla Bioengineering Institute, La Jolla, CA, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA

* To whom correspondence should be addressed. E-mail: pcabrales{at}ucsd.edu.

The objective of this work was to test the hypothesis that the limitation of NO availability accentuates microvascular reactivity to oxygen. The awake hamster chamber window model was rendered hypoxic and hyperoxic by ventilation with 10% and 100% oxygen. Systemic and microvascular parameters were determined in the two conditions and compared to normoxia, in a group receiving the nitric oxide (NO) scavenger nitronyl nitroxide and a control group receiving only the vehicle (saline). Mean arterial pressure (MAP) did not change with different gas mixtures during infusion of the vehicle, but increased significantly in the NO depleted group. NO scavenging increased the reactivity of microvessels to the changed oxygen supply, causing the arteriolar wall to significantly increase oxygen consumption. Tissue pO2 was correspondingly significantly reduced during NO scavenger infusion. The present findings support the hypothesis that microvascular oxygen consumption is proportional to oxygen induced vasoconstriction. The effect of oxygen on vascular tone is modulated by NO. As a consequence, NO acts as a regulator of the vessel wall oxygen consumption. The vessel wall consumes oxygen in proportion to the local pO2, and an impairment of NO availability renders the circulation more sensitive to changes in the oxygen supply.




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