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J Appl Physiol (November 2, 2006). doi:10.1152/japplphysiol.01102.2006
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Submitted on September 30, 2006
Accepted on October 26, 2006

The production of reactive oxygen and nitrogen species by skeletal muscle

Malcolm J Jackson1*, Deborah Pye1, and Jesus Palomero1

1 Metabolic and Cellular Medicine, University of Liverpool, Liverpool, Merseyside, United Kingdom

* To whom correspondence should be addressed. E-mail: m.j.jackson{at}liverpool.ac.uk.

Skeletal muscle has been recognised as a potential source for generation of reactive oxygen and nitrogen species (ROS) for more than 20 years. Initial investigations concentrated on the potential role of mitochondria as a major source for generation of superoxide as a 'by-product' of normal oxidative metabolism, but recent studies have identified multiple sub-cellular sites where superoxide or nitric oxide are generated in regulated and controlled systems in response to cellular stimuli. Full evaluation of the factors regulating these processes and the functions of the ROS generated is important in understanding the redox biology of skeletal muscle.




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