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J Appl Physiol (August 29, 2003). doi:10.1152/japplphysiol.01091.2002
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Submitted on November 27, 2002
Accepted on August 23, 2003

Effect of hindlimb suspension on the functional properties of slow and fast soleus fibers from three strains of mice

Julian E Stelzer1 and Jeffrey J Widrick1*

1 Department of Exercise and Sport Science, Oregon State University, Corvallis, OR, USA

* To whom correspondence should be addressed. E-mail: jeff.widrick{at}orst.edu.

Cross-sectional area (CSA), peak Ca2+-activated force (Po), Po/CSA, and unloaded shortening velocity (Vo) were measured in slow (containing type I myosin heavy chain, MHC) and fast (containing type II MHC) chemically skinned soleus muscle fiber segments obtained from three strains of weight bearing and 7 day hindlimb suspended (HS) mice. HS reduced soleus slow MHC content (from ~50% to ~33%) in CBA and ICR strains without effecting slow MHC content in C57BL/6 mice (~20% of total MHC). Two-way ANOVA revealed HS-induced reductions in CSA, Po, and Po/CSA of slow and fast fibers from all strains. Fiber Vo was elevated post-HS, but not consistently across strains. No MHC x HS treatment interactions were observed for any variable for C57BL/6 and CBA mice and the two significant interactions found for the ICR strain (CSA, Po) appeared related to inherent differences in slow vs. fast fiber CSA. In the mouse HS models studied here, fiber atrophy and contractile dysfunction were partially dependent on animal strain and generally independent of fiber MHC isoform content.




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