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J Appl Physiol (February 27, 2004). doi:10.1152/japplphysiol.01087.2003
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Submitted on October 7, 2003
Accepted on February 20, 2004

Human ACE I/D polymorphism is associated with individual differences in exercise heat tolerance

Yuval Heled1*, Daniel S Moran1, Liran Mendel1, Arie Laor1, Elon Pras1, and Yair Shapiro1

1 Sheba Medical Center, Heller Institute of Medical Research, Tel Aviv University, Tel Hashomer, Israel; Sheba Medical Center, Danek Gartner Institue of Human Genetics, Tel Aviv University, Tel Hashomer, Israel

* To whom correspondence should be addressed. E-mail: yheled{at}sheba.health.gov.il.

We hypothesized that there is an association between the ACE I/D polymorphism with the variability in exercise heat tolerance in humans. 58 Caucasian males were exposed to a 2h exercise heat tolerance test. We analyzed the association between their heat tolerance levels with the ACE DD (N= 25) and I+ (N=33) genotypes and with various anthropometrical parameters and aerobic fitness. It was found that the relative changes in body core temperature, heart rate and heat storage during the 120 min exposure to exercise heat stress was consistently lower in the I+ genotype group compared to the DD genotype group (0.8±0.2°C vs. 1±0.1°C; p<0.05, 17.7±1.8 W.M-2 vs. 19.8±1.3 W.M-2; p<0.05 and 33±7bpm vs. 44±5bpm, respectively; p=0.06). No significant association was found between heat strain response and the anthropometrical measurements or aerobic fitness in the various genotype groups. We suggest that the ACE I+ polymorphism may be considered as a possible candidate marker for increased heat tolerance.




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