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J Appl Physiol (April 5, 2002). doi:10.1152/japplphysiol.01084.2001
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Articles in PresS, published online ahead of print April 5, 2002
J Appl Physiol, 10.1152/jap.01084.2001
Submitted on October 29, 2001
Accepted on March 21, 2002

Dietary nucleotides prevent decrease in cellular immunity in ground-based microgravity analog

Keiko Yamauchi1, Nathan W Hales1, Sandra M Robinson2, Michael L Niehoff2, Ramesh Vani1, Neal R Pellis3, and Anil D Kulkarni4*

1 Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA
2 Department of Surgery, Saint Louis School of Medicine, St. louis, MO, USA
3 Bioastronautics, NASA Johnson Space Center, Houston, TX, USA
4 Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Surgery, Saint Louis School of Medicine, St. louis, MO, USA

* To whom correspondence should be addressed. E-mail: anil.d.kulkarni{at}uth.tmc.edu.

Microgravity and stress of space flights result in immune dysfunction. The role of nutrition especially nucleotide supplementation has become an area of intensive research and significant interest in immunomodulation for maintenance of cellular immune responses. The studies presented here evaluate plausibility of administering nucleotides to obviate immune dysfunction in earth-based in vivo analog of microgravity (MMG) as studied in antiorthostatic tail suspension (AOS) of mice. Mice are divided into 3 housing group; group, isolation and AOS. Mice were fed either control chow diet (CD), RNA (CDR), adenine (CDA) or uracil (CDU) supplemented CD for one week duration of experiments. In AOS mice, supplemental nucleotides significantly increased in vivo lymph node proliferation and ex vitro lymphoproliferation response to alloantigen and mitogens respectively, and IL-2 & INF-{gamma} production. Lower corticosterone level was observed in CDU as compared with CD. These results suggest that exogenous nucleotide supplementation, especially uracil, of normal diet is beneficial in maintenance and restoration of immune response during the microgravity analog conditions.




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M. J. Pecaut, G. M. Miller, G. A. Nelson, and D. S. Gridley
Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses
J Appl Physiol, July 1, 2004; 97(1): 29 - 38.
[Abstract] [Full Text] [PDF]


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