| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 The Jackson Laboratory, Bar Harbor, Maine, United States
2 The Jackson Laboratory, United States
* To whom correspondence should be addressed. E-mail: ksven{at}jax.org.
The breadth of genetic and phenotypic variation among inbred strains is often under appreciated because assessments include only a limited number of strains. Evaluation of a larger collection of inbred strains provides not only a greater understanding of this variation, but collectively mimics much of the variation observed in human populations. We used a high-throughput phenotyping protocol to measure females and males of 43 inbred strains for body composition (weight, fat, lean tissue mass and bone mineral density), plasma triglycerides, HDL and total cholesterol, glucose, insulin, and leptin levels while mice consumed a high fat, high cholesterol diet. Mice were fed a chow diet until they were 6-8 weeks old, and then fed the high fat diet for an additional 18 weeks. As expected, broad phenotypic diversity was observed among these strains. Significant variation between the sexes was also observed for most traits measured. Additionally, the response to the high fat diet differed considerably among many strains. By testing such a large set of inbred strains for many traits, multiple phenotypes can be considered simultaneously and thereby aid in the selection of certain inbred strains as models for complex human diseases. These data are publicly available in the web accessible Mouse Phenome Database (http://www.jax.org/phenome), an effort established to promote systematic characterization of biochemical and behavioral phenotypes of commonly used and genetically diverse inbred mouse strains. Data generated by this effort builds on the value of inbred mouse strains as a powerful tool for biomedical research.
This article has been cited by other articles:
|
|
 |
|
  T. H. Meek, B. P. Lonquich, R. M. Hannon, and T. Garland Jr Endurance capacity of mice selectively bred for high voluntary wheel running J. Exp. Biol., September 15, 2009; 212(18): 2908 - 2917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Romero-Aleshire, M. K. Diamond-Stanic, A. H. Hasty, P. B. Hoyer, and H. L. Brooks Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R587 - R592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Hayes, B. M. Young, and M. T. Pletcher Expression Quantitative Trait Loci Mapping Identifies New Genetic Models of Glutathione S-Transferase Variation Drug Metab. Dispos., June 1, 2009; 37(6): 1269 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Grubb, T. P. Maddatu, C. J. Bult, and M. A. Bogue Mouse Phenome Database Nucleic Acids Res., January 1, 2009; 37(suppl_1): D720 - D730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-A. Cornier, D. Dabelea, T. L. Hernandez, R. C. Lindstrom, A. J. Steig, N. R. Stob, R. E. Van Pelt, H. Wang, and R. H. Eckel The Metabolic Syndrome Endocr. Rev., December 1, 2008; 29(7): 777 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Stylianou, S. R. Langley, K. Walsh, Y. Chen, C. Revenu, and B. Paigen Differences in DBA/1J and DBA/2J reveal lipid QTL genes J. Lipid Res., November 1, 2008; 49(11): 2402 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Svenson, N. Ahituv, R. S. Durgin, H. Savage, P. A. Magnani, O. Foreman, B. Paigen, and L. L. Peters A new mouse mutant for the LDL receptor identified using ENU mutagenesis J. Lipid Res., November 1, 2008; 49(11): 2452 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Li, K. L. Svenson, L. R. B. Donahue, L. L. Peters, and G. A. Churchill Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels Physiol Genomics, October 8, 2008; 33(1): 26 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Adams and L. van der Weyden Contemporary approaches for modifying the mouse genome Physiol Genomics, August 1, 2008; 34(3): 225 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Su, S.-w. Tsaih, J. Szatkiewicz, Y. Shen, and B. Paigen Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ J. Lipid Res., July 1, 2008; 49(7): 1500 - 1510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Blasiole, A. T. Oler, and A. D. Attie Regulation of ApoB Secretion by the Low Density Lipoprotein Receptor Requires Exit from the Endoplasmic Reticulum and Interaction with ApoE or ApoB J. Biol. Chem., April 25, 2008; 283(17): 11374 - 11381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, X. Chen, J. Aravindakshan, and M. R. Sairam Changes in Adiponectin and Inflammatory Genes in Response to Hormonal Imbalances in Female Mice and Exacerbation of Depot Selective Visceral Adiposity by High-Fat Diet: Implications for Insulin Resistance Endocrinology, December 1, 2007; 148(12): 5667 - 5679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cutler, L. A. Marshall, N. Chin, H. Baribault, and P. D. Kassner Significant gene content variation characterizes the genomes of inbred mouse strains Genome Res., December 1, 2007; 17(12): 1743 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Dwinell Physiological genomics: from bench to bedside Exp Physiol, November 1, 2007; 92(6): 987 - 987. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
