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J Appl Physiol (August 9, 2002). doi:10.1152/japplphysiol.01064.2001
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Articles in PresS, published online ahead of print August 9, 2002
J Appl Physiol, 10.1152/jap.01064.2001
Submitted on October 22, 2001
Accepted on July 30, 2002

Effects of microgravity elicited by parabolic flight on abdominal aortic pressure and heart rate in rats

Hidefumi Waki1*, Tsuyoshi Shimizu1, Kiyoaki Katahira2, Tadanori Nagayama1, Masao Yamasaki1, and Shinichiro Katsuda1

1 Department of Physiology, Fukushima Medical University, Fukushima, Japan
2 Experimental Animal Center, Fukushima Medical University, Fukushima, Japan

* To whom correspondence should be addressed. E-mail: wakihidefumi{at}aol.com.

Abdominal aortic pressure (AAP), heart rate (HR) and aortic nerve activity (ANA) during parabolic flight were measured using a telemetry system to clarify the acute effect of microgravity (µG) on hemodynamics in rats. While conscious, AAP increased up to 119±3 mmHg on exposure to µG compared with the value at 1G (95±3 mmHg, p<0.001), while AAP decreased immediately on exposure to µG under urethane-anesthesia (µG: 72±9 mmH v.s. 1G: 78±8 mmHg, p<0.05). HR also increased during µG in conscious animals (µG: 349±12 bpm v.s. 1G: 324±9 bpm, p<0.01), although no change was observed under anesthesia. ANA, which was measured under anesthesia, decreased in response to acute µG exposure (µG: 33±7 counts/sec v.s. 1G: 49±5 counts/sec, p<0.01). These results suggest that µG essentially induces a decrease of arterial pressure; however emotional stress and body movements affect the responses of arterial pressure and HR during exposure to acute µG.




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