Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol (May 10, 2007). doi:10.1152/japplphysiol.01061.2006
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Submitted on September 21, 2006
Accepted on May 4, 2007

Prior Exercise Speeds Pulmonary O2 Uptake Kinetics by Increases in Both Local Muscle O2 Availability and O2 Utilization

Darren S. DeLorey1*, John M. Kowalchuk2, Aaron P. Heenan2, Gregory R. duManoir2, and Donald H. Paterson3

1 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, United States
2 School of Kinesiology, The University Western Ontario, London, Canada
3 School of Kinesiology, University of Western Ontario, London, Canada

* To whom correspondence should be addressed. E-mail: ddelorey{at}mcw.edu.

Effects of prior exercise on heavy-intensity pulmonary O2 uptake (VO2p), leg blood flow (LBF) and muscle deoxygenation kinetics was examined. Seven subjects (27 (5) yrs; mean (SD)) performed transitions (n=3; 8 min) from passive knee-extension (KE) following no warm-up (HVY 1) and heavy-intensity ( {Delta}50%, 8 min; HVY 2) KE exercise. VO2p, LBF and vastus lateralis oxy- (O2Hb), deoxy-(HHb) and total (Hbtot) hemoglobin/myoglobin were measured continuously. Phase 2 VO2p, LBF and HHb data were fit with a mono-exponential. The HHb time delay (TD) was determined and an HHb effective time constant (HHb-MRT=TD + {tau}) calculated. Prior exercise resulted in a speeding (p<0.05) of phase 2 VO2p kinetics (HVY 1: 42 (6) s; HVY 2: 37 (8) s), with no change in phase 2 (HVY 1: 1.43 (0.21) L/min; HVY 2: 1.48 (0.21) L/min) or slow component (HVY 1: 0.18 (0.08) L/min; HVY 2: 0.18 (0.09) L/min) amplitude. O2Hb and Hbtot were elevated following prior exercise. {tau}LBF (HVY 1: 39 (7) s; HVY 2: 47 (21) s; p=0.48) and HHb-MRT (HVY 1: 23 (4) s; HVY 2: 21 (7) s; p=0.63) were unaffected by prior exercise. However, the increase in HHb (HVY 1: 21 mM (10); HVY 2: 25 mM (10); p<0.001) and the HHb-to- VO2p ratio (HHb/VO2p) (HVY 1: 14 mM/L/min (6); HVY 2: 17 mM/L/min (5); p<0.05) were greater following prior exercise. These results suggest the speeding of phase 2 {tau} VO2p was because of elevated local O2 availability and greater O2 extraction following prior heavy-intensity exercise.




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