Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol (April 30, 2004). doi:10.1152/japplphysiol.01058.2003
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Submitted on September 30, 2003
Accepted on April 27, 2004

Adaptation to Lengthening Contraction-Induced Injury in Mouse Muscle

Christopher P Ingalls1, J C Wenke2, Talal Nofal3, and R B Armstrong2*

1 Muscle Biology Laboratory, Department of Health and Kinesiology, Texas A&M University, College Station, Texas, USA; Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, Georgia, USA
2 Muscle Biology Laboratory, Department of Health and Kinesiology, Texas A&M University, College Station, Texas, USA
3 Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, Georgia, USA

* To whom correspondence should be addressed. E-mail: rb-armstrong{at}hlkn.tamu.edu.

Adaptations to repeated bouts of injury-inducing lengthening contractions were studied in mouse anterior crural muscles. Five bouts of 150 lengthening contractions were performed in vivo, with each bout separated by 2 wk of rest. Three primary observations were made. First, there was little, if any, attenuation in the immediate isometric torque losses after lengthening contractions at "physiological" stimulation frequencies (i.e., < 125 Hz), although there was a pronounced decrease in torque loss at higher frequencies between the 1st and 2nd bouts. Second, the immediate losses in strength that occurred after all 5 lengthening contraction bouts could be explained in part by excitation-contraction uncoupling. Third, the most important adaptation was a significant enhancement in the rate of recovery of strength following the lengthening contractions. It is probable that the accelerated rate of strength recovery resulted from the more rapid loss and subsequent recovery of myofibrillar protein observed after the 5th bout.




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