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Articles in PresS, published online ahead of print April 19, 2002
J Appl Physiol, 10.1152/jap.01044.2001
Submitted on October 16, 2001
Accepted on April 17, 2002
1 Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia; Anatomy and Human Biology, University of Western Australia, Perth, Western Australia, Australia
2 Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia; Department of Paediatrics, University of Western Australia, Perth, Western Australia, Australia
3 Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
* To whom correspondence should be addressed. E-mail: janak{at}ichr.uwa.edu.au.
Previous studies of alveolarization have used rats or lambs, however, neither closely reflect human alveolar development. We characterized alveolar development in rabbits (n=3-7 /group) 28 days gestation (dg)-9 months (m) to determine whether they followed the human pattern more closely. The right lung was made up of 30% alveolar and 50% duct space 28dg-3 days (d), and 50% and 30% respectively 14d-9m. Tissue fraction and alveolar wall thickness decreased by 40% 28dg-birth. At birth, approximately 4.5% of the number of alveoli seen at 9m were present, with alveolar number increasing progressively well into adulthood. The rate of alveolar formation was high around birth decreasing progressively with age. Alveolar volume increased more than 2-fold (28dg-birth) and continued to increase postnatally to 16 weeks. Surface fraction decreased, by 17% (28dg-3d), after which it remained uniform. Our findings suggest that the timing of onset of alveolarization in humans and rabbits is similar and that rabbits may be used to model postnatal influences on alveolar development.
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